UPMC Physician Resources

Physicians and Researchers Present at the 2014 Annual Meeting for the American Heart Association

The UPMC Heart and Vascular Institute was well-represented at the 2014 Annual Meeting for the American Heart Association in Chicago. Faculty research was featured in both oral and poster presentations throughout the conference, including:

Sunday, November 16: 

  • Heart Failure: CRT and Pacing (POSTER)
    Comparative Outcomes after Cardiac Resynchronization Therapy in Patients with Right Ventricular Pacing versus Native Wide Left Bundle Branch Block
    Presented by: Bhupendar Tayal, Antonia Delgado-Montero, Akiko Goda, Keiko Ryo, Samir Saba, Niels Risum, Hvidovre Sygehus, Peter Sogaard, John Gorcsan III
  • Heart Failure: CT and Pacing (POSTER)
    Global Longitudinal Strain Combined With Radical Strain Delay Before Cardiac Resynchronization Therapy is Associated With Long Term Survival
    Presented by: Antonia Delgado-Montero, Bhupendar Tayal, Keiko Ryo, Akiko Goda, David Schwartzman, Samir Saba, John Gorcsan III
  • Chronic Ischemic Heart Disease (POSTER)
    Prediction of Mitral Regurgitation Progression With Advanced Ischemic Cardiomyopathy – A Multi-Modality Study
    Presented by: Kenya Kusunose, Nancy Obuchowski, João Cavalcante, Rayji S. Tsutsui, Zoran B. Popovic, James D. Thomas, Milind Y. Desai, Scott D. Flamm, Brian P. Griffin, Deborah H. Kwon
  • Heart Rate-independent Qt Variability in Congenital Long Qt Syndrome (POSTER)
    Presented by: Jan Nemec
  • Vascular Disease and Pulmonary Hypertension (POSTER)
    Metabolic Syndrome and Pulmonary Hypertension Due to Left Heart Disease
    Presented by: Rebecca R. Vanderpool, Sebastian Shterental, Timothy N. Bachman, Mark T. Gladwin, Marc A. Simon

Monday, November 17:

  • Imaging Heart Failure Substrates for Prognosis (INVITED TALK)
    Presented by: Eric Schelbert
  • Echocardiography in the Context of Multi-Modality Imaging (POSTER)
    Echocardiographic Estimation of Myocardial Scar by Segmental Longitudinal Strain in Patients with Ischemic Cardiomyopathy and Left Bundle Branch Block: Comparison with Quantitative Cardiac Magnetic Resonance Imaging Late Gadolinium Enhancement
    Presented by: Bhupendar Tayal, Niels Risum, Hvidovre Sygehus, Antonia Delgado-Montero, Allan Iversion, Thomas Fritz Hansen, John Gorcsan III, Peter Sogaard
  • Echocardiography: Evaluation of RV function – Role of Strain Imaging (POSTER)
    Right Ventricular Remodeling is Additive to Global Longitudinal Strain in Predicting Long Term Survival in Patients with Pulmonary Hypertension
    Presented by: Akiko Goda, Keiko Ryo, Antonia Delgado-Montero, Bhupendar Tayal, Marc Simon, Michael A. Mathier, John Gorcsan III
  • Echocardiography: Evaluation of RV function – Role of Strain Imaging (POSTER)
    The Additive Effects of Tricuspid Regurgitation and Pressure Overload in Pulmonary Hypertension on Three-Dimensional Right Ventricular Mechanics and Patient Outcomes
    Presented by: Keiko Ryo, Akiko Goda, Antonia Delgado-Montero, Bhupendar Tayal, Marc A. Simon, Michael A. Mathier, John Gorcsan III
  • Progress in Clinical Pediatric Heart Failure/Transplantation (POSTER)
    Presented by: B. Feingold, C.M. Salgado, M. Reyes-Mugica, S. Drant, S.A. Miller, P. Kellman, E.B. Schelbert, T.C. Wong
  • Utility of the Wearable Cardioverter-Defibrillator for Patients With Newly Diagnosed Non-Ischemic Cardiomyopathy? (POSTER)
    Presented by: Madhur Singh
  • Bedside Ultrasound Evaluation of Right Atrial Pressure to Predict Acute Decompensated Heart Failure 30-Day Readmission
    Presented by: Fredrick G. Schnatz III, Sneha N. Parikh, Jonathan E. Leeman, Madhurmeet Singh, Flordeliza S. Villanueva, Marc A. Simon, John H. Pacella

Tuesday, November 18:

  • Microcirculation and Cerebral/Coronary/Peripheral (POSTER)
    Sonoreperfusion Therapyfor Microvascular Obstruction Using Microbubbles and Low Dose tPa
    Presented by: Sebastiaan Roos, Rick Schnatz, John Pacella
  • Dickinson W. Richards Lecture: Frontiers in Pulmonary Hypertension (ORAL)
    Adverse Right Ventricular Remodeling by Three Dimensional Echocardiographic Wall Motion Tracking in Pulmonary Hypertension is Associated with Patient Outcomes
    Presented by: Keiko Ryo, Akiko Goda, Antonia Delgado-Montero, Bhupendar Tayal, Marc A. Simon, Michael A. Mathier, John Gorcsan III
  • Risk Factors, Biomarkers, Risk Prediction II (POSTER)
    Higher Levels of Plasminogen-Activator Inhibitor I Are Associated with Progression of Coronary Artery Calcification in Middle-Aged Women: The Study of Women’s Health Across the Nation (SWAN) Heart Study
    Presented by: Norman C. Wang, Karen A. Matthews, Emma JM Barinas-Mitchell, Chung-Chou H. Chang, Samar R. El Khoudary
  • Emerging Technologies II (POSTER)
    Targeted Therapeutic Gene Knockdown Using Ultrasound and Microbubble-mediated Delivery of a Transcription Factor Decoy
    Presented by: Jonathan Kopecheck
  • Heart Failure: Exercise and More… (POSTER)
    Right Ventricular Function is Associated with Long Term Survival in Patients Undergoing Cardiac Resynchronization Therapy
    Presented by: Antonia Delgado-Montero, Bhupendar Tayal, Keiko Ryo, Akiko Goda, David Schwartzman, Samir Saba, John Gorcsan III
  • Vasodilator Therapy on Hemodynamics and Exercise Capacity in Patients With Exercise Induced Pulmonary Hypertension Due to Pulmonary Vascular Disease or Heart Failure With Preserved Ejection Fraction (POSTER)
    Presented by: David C. Ishizawar, Matthew Lander, Michael A. Mathier
  • Multimodality Imaging of Cardiac Stem Cells
    Presented by: Flordeliza Villanueva

For more information, visit the conference site.





Program Improves Diabetes Control in World’s Poorest Children, Pitt Public Health Finds

PITTSBURGH, Nov. 25 2014 – A nonprofit program that brings diabetes care and education to some of the world’s poorest children has successfully improved control of the disease, according to a University of Pittsburgh Graduate School of Public Health analysis published in the journal Diabetes Research and Clinical Practice. It is the first scientific evidence to show that improvement in long-term blood sugar control in type 1 diabetes is possible in sub-Saharan African youth.

The International Diabetes Federation Life for a Child (LFAC) program’s approach to providing care to children with type 1 diabetes in Rwanda led to major reductions in HbA1c, a long-term measure of blood sugar. The proportion of children who had an HbA1c level of more than 14 percent, a potentially lethal level, fell from 31 percent to 9 percent. The improvement was greatest in the children who had access to blood sugar testing supplies and regularly monitored their blood glucose levels.

“Type 1 diabetes can be a very difficult disease to manage, and, if not properly controlled, it is deadly,” said senior author Trevor Orchard, M.D., professor of epidemiology at Pitt Public Health. “When coupled with poverty, food insecurity and severely limited health care provision that many of the children in sub-Saharan Africa face, the need for proven programs to help these children control their diabetes becomes vital.”

Type 1 diabetes, usually diagnosed in children and young adults, happens when the body does not produce insulin, a hormone that is needed to convert sugar into energy.

LFAC supports the provision of insulin, glucose monitoring supplies, diabetes education, advice and training to children and youth with diabetes in developing countries. In Rwanda, the program provides assistance through the Association Rwandaise des Diabetiques (ARD) in the city of Kigali.

Dr. Orchard and his team followed and regularly measured the HbA1c levels in 214 people under age 25 who enrolled in the program between June 2009 and November 2010.

HbA1c develops when sugar binds to hemoglobin, a protein within red blood cells, in the blood. The higher the HbA1c, the greater the risk of developing diabetes-related complications, like heart disease, blindness and nerve damage. Those without diabetes typically have an HbA1c between 4 and 5.7 percent. For people with diabetes, an HbA1c level of less than 7 percent is considered good control.

In the Rwandan children that Dr. Orchard’s team followed, the average HbA1c initially was 11.2 percent. After two years in the program, the average fell to 9.8 percent.

Dr. Orchard became involved in the program in Rwanda in 2007 when it had only 25 children. LFAC has now enrolled more than 1,000 children and youth. Pitt Public Health sends at least one graduate student every year to assist with the program and the required annual assessments of the children enrolled. Dr. Orchard and a colleague from Northwestern University in Chicago, Deborah Edidin M.D., also visit Rwanda regularly to help develop and provide care and education for the children.

“It is very encouraging to see the Rwandan children get better control of their blood sugar levels thanks to this unique collaborative effort between the LFAC, ARD and Pitt,” said Dr. Orchard. “However, more work is needed. Only about 12 percent of the Rwandan children met American Diabetes Association glucose control goals, compared with 32 percent of U.S. children.”

A key part of controlling type 1 diabetes is regular blood sugar monitoring, which allows patients to adjust their insulin levels based on test results. Children who were better able to monitor their blood sugar had better HbA1c levels. In some cases, a lack of testing supplies prohibited children from testing their blood sugar as frequently as recommended.

Disturbingly, Dr. Orchard’s team also found that, as HbA1c levels improved, high blood pressure emerged as a major problem such that over 40 percent of the youth were hypertensive.

“This is troubling,” said Dr. Orchard. “Many of our participants were very young children during the Rwandan genocide of 1994 and grew up malnourished and underweight. It is possible to attribute some of the increasing blood pressure to weight gain and rehydration after enrollment in the program. Salt also often is used in food preparation and preservation in sub-Saharan Africa, so this may be a factor as well. Unfortunately, very few participants are able to take blood pressure medication due to limited supplies and prohibitive prices.”

Dr. Orchard noted that continued study is needed to better understand the causes of the high blood pressure among the Rwandan children receiving care for type 1 diabetes, as well as to determine how best to develop a sustainable program to maintain this improved care.

Additional researchers on this project are Sara L. Marshall, Ph.D., Vincent C. Arena, Ph.D., Dorothy J. Becker, M.B.B.Ch., Clareann H. Bunker, Ph.D., Ronald E. LaPorte, Ph.D., and Laurien Sibomana, M.S., all of Pitt; Graham Ogle, M.B.B.S., of the International Diabetes Federation Life for a Child Program and Australian Diabetes Council; and Crispin Gishoma, Francois Gishoma, and Veaste Kaberuka, all of the Association Rwandaise des Diabetiques.

This work was largely funded by donations to the Life for a Child –Pitt Initiative. Directions for donating to the initiative can be found at: http://www.upmc.com/lifeforachildprogram

Pitt Public Health Biostatistician Receives Fellowship from World’s Top Scientific Society

PITTSBURGH, Nov. 24, 2014 – James J. Schlesselman, Ph.D., professor emeritus of the University of Pittsburgh Graduate School of Public Health, has been named a Fellow of the American Association for the Advancement of Science (AAAS).

AAAS is the world’s largest general scientific society, fellowship in which is an honor bestowed upon AAAS members by their peers. This year, 401 members will be awarded fellowship to recognize their scientifically or socially distinguished efforts to advance science or its applications. This year’s AAAS Fellows will be formally announced in the journal Science on Friday.

Dr. Schlesselman, who retired from Pitt Public Health’s Department of Biostatistics, remains active in the field of biostatistics and epidemiology, doing consulting work in the United States and abroad.

“To be recognized by the AAAS for my work is humbling. All that I sought to do over the years is encapsulated in the title of an article by the late mathematical statistician Jerzy Neyman: ‘Statistics – Servant of All Sciences,’” which ran in Science in 1955, said Dr. Schlesselman.

As part of the AAAS Section of Statistics, Dr. Schlesselman was elected as an AAAS Fellow for his body of work in statistical methods and leadership; key studies of vaccines, nutrition and reproductive health; and expert advice to international and U.S. governmental agencies.

“This AAAS Fellowship recognizes Dr. Schlesselman’s significant methodological contributions and leadership as a statistical scientist. We are very fortunate to have him as our colleague in the discipline and in our department,” said Sally C. Morton, Ph.D., professor and chair of the Department of Biostatistics at Pitt Public Health.

Dr. Schlesselman received his Ph.D. in statistics from Princeton University in 1971 while working as a biostatistician at the National Institutes of Health (NIH) in studies of human reproduction, vaccine field trials, nutrition and disabilities. He served at the NIH until 1981, rising to the rank of chief of the biometry branch in the National Institute of Child Health and Human Development.

From there he served on the faculty at the Uniformed Services University of the Health Sciences in Bethesda, Md., Pitt’s School of Medicine and the University of Miami before returning to Pitt in 2004 to lead the biostatistics facility at the University of Pittsburgh Cancer Institute.

Over the years, Dr. Schlesselman has been called on to advise and work with components of the World Health Organization, International Atomic Energy Agency, U.S. Food and Drug Administration, Centers for Disease Control and Prevention,  the NIH and the Agency for International Development, among others.

The tradition of AAAS Fellows began in 1874. Dr. Schlesselman and the other 400 fellows will be presented with an official fellowship certificate and rosette pin on Feb. 14, 2015, during the AAAS Annual Meeting in San Jose, Calif.

International Team Reveals Barriers to Public Health Data-Sharing; Proposes Life-Saving Solutions

PITTSBURGH, Nov. 24, 2014 –Barriers to the sharing of public health data hamper decision-making efforts on local, national and global levels, and stymie attempts to contain emerging global health threats, an international team led by the University of Pittsburgh Graduate School of Public Health announced today.

The analysis, published in the journal BMC Public Health and funded by the Bill & Melinda Gates Foundation and the National Institutes of Health (NIH), classifies and examines the barriers in order to open a focused international dialogue on solutions.

“Data on disease surveillance, intervention coverage, vital statistics and mortality represent some of the most widely collected but also some of the most underused data,” said lead author Willem G. van Panhuis, M.D., Ph.D., assistant professor of epidemiology at Pitt Public Health. “Innovative methods for collection of new data are developed all the time, but a framework to share all these data for the global good is seriously lacking. Investments in routine data systems will better position health officials to address ongoing challenges as well as new public health threats, such as the current Ebola epidemic in West Africa.”

Dr. van Panhuis and his team – which included experts in ethics and law, as well as public health and epidemiology – identified more than 1,400 scientific publications related to public health data-sharing, ultimately winnowing them down to the 65 most relevant articles. From those, they determined 20 real or perceived barriers to data-sharing in public health and classified them into six categories: technical, motivational, economic, political, legal and ethical.

“These barriers and categories describe a landscape of challenges that must be addressed comprehensively, not piecemeal,” said senior author Donald S. Burke, M.D., Pitt Public Health dean and UPMC-Jonas Salk Chair of Global Health. “We must work together as a global community to develop solutions and reap the benefits of data-sharing, which include saving lives through more efficient and effective public health programs.”

The team found that most technical, motivational and economic barriers are deeply embedded in much larger challenges of health information system capacity, particularly in low- and middle-income countries. Solutions lie in sufficiently funding such systems through international cooperation and shared development of data and infrastructure used across agencies and institutes.

The political, legal and ethical barriers will require a dialogue across international agencies that should include the World Health Organization, World Intellectual Property Organization and World Trade Organization, as well as the countries, development and funding agencies, and experts in ethics and law. The team proposes the creation of a treaty for data-sharing in public health across the world, as well as a commission to monitor, mediate and facilitate data-sharing.

“Identifying and classifying these barriers was the first step toward harnessing the potential of data for a new era in population health,” said Dr. van Panhuis. “As our knowledge of these barriers increases, so will the opportunities for solutions.”

Additional researchers on this project are Proma Paul, M.H.S., and John Grefenstette, Ph.D., both of Pitt Public Health; Claudia Emerson, Ph.D., of the University of Toronto; Richard Wilder, J.D., of the Bill & Melinda Gates Foundation; Abraham J. Herbst, M.B.Ch.B., M.Sc., F.F.C.H.(S.A.), of both the INDEPTH Network in Ghana and the University of KwaZulu-Natal in South Africa; and David Heymann, M.D., of the Chatham House London.

This research was funded by the Bill & Melinda Gates Foundation Vaccine Modeling Initiative grant no. 49276 and the NIH’s National Institute of General Medical Sciences grant no. 5U54GM088491.

Childhood Cancer Focus of St. Baldrick’s Foundation Research Grant to Children’s Hospital of Pittsburgh of UPMC

PITTSBURGH, Nov. 21, 2014 – To improve information flow about childhood cancers, Jean M. Tersak, M.D., an oncologist in the Division of Pediatric Hematology/Oncology at Children’s Hospital of Pittsburgh of UPMC, has been awarded a one-year, $50,000 grant from the St. Baldrick’s Foundation, a volunteer-driven charity dedicated to raising money for childhood cancer research.

Dr. Tersak’s is one of 40 infrastructure grants totaling more than $2.5 million awarded by St. Baldrick’s to support pediatric oncology research. These grants provide resources to institutions to conduct more research and enroll more children in ongoing clinical trials.

The funding will help to support efforts to enhance website communication of research activities to make information more easily accessible to potential patients, families, and referring physicians. Additionally, funding will support the transition to a new database to increase efficiency and refine ability to query the database as a more effective tool to conduct institutional research.

“This generous grant from St. Baldrick’s will help us to be sure that our medical treatments are more widely known and available to anyone who may need them to battle a diagnosis of cancer as a child or young adult,” said Dr. Tersak, who also directs the Survivorship Program at Children’s Hospital. “The grant will increase the efficiency of our program and increase awareness of novel treatments available to patients form our region and beyond.”

“These grants are critically important to saving children’s lives, and would not be possible without our dedicated volunteers and generous donors who believe kids deserve better than medicine is currently able to provide,” said Kathleen Ruddy, chief executive officer for the St. Baldrick’s Foundation.

“Each day in my work, I encounter patients who have been helped along the way through the tremendous efforts of St. Baldrick’s,” added Dr. Tersak, also principal investigator, Children’s Oncology Group.

Dr. Tersak has a special interest in caring for survivors of childhood cancer, including evaluation for medical late effects of treatment and the quality of life in these survivors. She is involved in national research to better understand late effects, ways to prevent them, and early intervention when they do occur.

The Division of Pediatric Hematology/Oncology at Children’s provides diagnosis, treatment and complete follow-up for children, adolescents, and young adults with cancer and blood disorders. The division is the largest, most comprehensive pediatric cancer and blood disease center in western Pennsylvania, eastern Ohio, and northern West Virginia and has been a member of the Children’s Oncology Group, a multi-institutional pediatric cancer research organization sponsored by the National Cancer Institute, since 1961. It’s one of the top-rated pediatric cancer programs in the United States as ranked by U.S. News & World Report.

For more information about Dr. Tersak, please visit www.chp.edu.

Early Diagnosis and Cord Blood Transplantation Prevents Permanent Brain Damage From Rare Inherited Disease, Children’s Hospital of Pittsburgh of UPMC Study Finds

PITTSBURGH, Nov. 19, 2014 – Umbilical cord blood from unrelated donors can halt the progression of the neurodegenerative disease Hurler syndrome if performed before the affected child is less than 9 months old, according to a Children’s Hospital of Pittsburgh of UPMC study that appears online in Annals of Neurology. The findings emphasize the need for early diagnosis of the condition, preferably through newborn screening programs.

Hurler syndrome is the most clinically severe form of an inherited disorder in which the patient lacks a key enzyme needed to break down complex sugars called glycosaminoglycans. The sugar buildup results in progressive organ deterioration and death in childhood. Affected children may not have symptoms until age 3, but the brain undergoes damage before symptoms present.

Umbilical cord blood transplantation from unrelated donors has previously been shown to improve neurological outcomes of children over 2 years of age and prolong life. Hematopoietic stem cells from the cord blood transplants provide a source for the normal enzyme that is donated to the deficient cells decreasing the accumulation of gycosaminoglycans.

Key findings of this study show that treatment of Hurler syndrome with umbilical cord blood transplantation before 9 months of age leads to normal cognitive development. The researchers found children transplanted at 12 and 25 months of age functioned cognitively at a level 2 to 5.3 years below that of those transplanted at 4 months. Early transplantation also predicted better outcomes for language skills and adaptive behaviors.

“The purpose of the study was to determine whether age at transplantation can predict cognitive outcomes,” said Maria Luisa Escolar, MD, MS, director, Program for the Study of Neurodevelopment in Rare Disorders, Children’s Hospital, and associate professor of pediatrics, University of Pittsburgh School of Medicine. “This study highlights the importance of early detection of brain diseases in babies and infants when brain growth is the most accelerated in life, placing them at increased vulnerability for permanent damage.”

Between June 1997 and February 2013, 31 children with Hurler syndrome underwent umbilical cord blood transplantation and were evaluated every six to 12 months thereafter for an average of seven years. Median age at transplantation was 13.8 months. The youngest babies in the study were diagnosed due to family history of the condition.

“Identification of asymptomatic children through statewide newborn screening programs is the only way to diagnose early and prevent brain damage to babies with no family history of Hurler syndrome,” Dr. Escolar said.

“Unfortunately, early diagnosis is often difficult as their initial symptoms may be common in the general population,” added Dr. Escolar. “Therefore, there is a need for newborn screening for Hurler syndrome and similar neurodegenerative diseases that can identify children before symptoms appear, giving the best opportunity for prompt intervention and optimal outcomes.”

Collaborators with Dr. Escolar on the study were Michele Poe, PhD, and Sarah Chagnon, MD, both with Children’s Hospital of Pittsburgh of UPMC.

Financial support for this work was received from the Caterina Marcus Foundation.

For more information on Dr. Escolar and the Program for the Study of Neurodevelopment in Rare Disorders, visit www.chp.edu/ndrd.

Child Abuse, Adversity Associated With Poor Health and Employment Outcomes Later in Life

PITTSBURGH, Nov. 18, 2014 – People who currently fall into low-income and educational brackets are up to five times as likely to have faced abuse and adversity during childhood as people who fall into higher socioeconomic groups, according to a University of Pittsburgh Graduate School of Public Health analysis of Allegheny County residents.

The findings, which will be presented Tuesday at the American Public Health Association’s (APHA) annual meeting in New Orleans, support the merit of “whole family” programs that seek to break the cycle of adversity and negative health, economic and social outcomes that persist over generations.

Eliminating childhood abuse and adversity significantly improves health – reducing heart disease by more than 26 percent and serious mental illness by more than 41 percent, the research team determined in a separate study presented Monday.

“Early childhood is a sensitive period of human development when abuse or parental problems can create lasting negative consequences later in life,” said lead investigator Todd M. Bear, Ph.D., director of the Office of Health Survey Research in Pitt Public Health’s Department of Behavioral and Community Health Sciences. “Our findings provide strong evidence that it is worthwhile for communities to invest in robust intervention programs that provide treatment, educational and employment opportunities, and positive role models to the whole family.”

The analyses used data from the 2009-2010 Allegheny County Health Survey, which interviewed 5,442 randomly selected residents of the county containing Pittsburgh.

Dr. Bear and his colleagues focused on six adverse childhood events reported by adult residents as having happened in their household when they were children: physical, sexual and emotional abuse, parental mental illness, parental substance abuse and domestic violence.

The research team, which included experts in epidemiology and psychiatry, found that:

  • Blacks had 2.5 times higher prevalence of childhood sexual abuse and greater rates of physical abuse when compared with whites.
  • People with a low socioeconomic status had 1.7 to 4.2 times higher prevalence for each of the six adverse childhood events compared with people of higher socioeconomic status.
  • People who reported they were unable to work also reported a prevalence of sexual abuse five times higher than those reporting employment.

The results are consistent with those of similar surveys conducted in other communities nationwide.

“We’ve found nothing to indicate that our findings are unique to Allegheny County,” said Dr. Bear. “These strong links between childhood adversity and poor socioeconomic status later in life, coupled with our findings that eliminating childhood abuse significantly prevents serious health consequences in adulthood, should be useful information for communities nationwide that are determining appropriate interventions to help their most vulnerable populations.”

Additional researchers on both these studies are Patricia I. Documét, M.D., Dr.P.H., Michael Marshal, Ph.D., Ronald Voorhees, M.D., M.P.H., and Edmund Ricci, Ph.D., M.Litt., all of Pitt.

Pitt Epidemiologist Honored for Innovations in Public Health

PITTSBURGH, Nov. 17, 2014 Lewis Kuller, M.D., Dr.P.H., former chair of the University of Pittsburgh Graduate School of Public Health’s Department of Epidemiology, today will receive the prestigious John Snow Award from the American Public Health Association (APHA) and the Royal Society for Public Health in England.

The award, which annually recognizes an outstanding scientist for excellence in epidemiologic practice or research, will be presented to Dr. Kuller in New Orleans at the 2014 APHA annual meeting.

“APHA’s recognition of our work in cardiovascular disease prevention, women’s health and, more recently, aging is a testament to the skill and expertise of our team at Pitt Public Health,” said Dr. Kuller, professor emeritus. “One of my mentors, Dr. Abraham Lilienfeld, was the first recipient of this award, so it is a true honor to follow in his footsteps.”

Awardees are chosen for their contributions to the improvement of human health or substantial reduction in burden of disease through innovations in public health practice based on clear epidemiologic foundations or implementation of epidemiologic approaches to the solution of health problems. Their contributions are practical, explicit and applied, rather than theoretical or implicit.

“Dr. Kuller was selected because of not only his enormous body of work contributing to the field of epidemiology, but also his impact on students and the next generation of epidemiologists,” said E. Oscar Alleyne, Dr.P.H., M.P.H., director of epidemiology at the Rockland County Health Department in New York and chair-elect of the APHA Epidemiology Section.

The Snow Award is one of the oldest in the field of epidemiology. It commemorates John Snow, M.D., a physician who practiced in 19th century Britain and is credited as one of the founding fathers of epidemiology, which is the branch of medicine that deals with the incidence, distribution and possible control of diseases and other factors relating to health.

Dr. Snow used disease incidence data and mapping to determine that a cholera outbreak in the mid-1850s was associated with a public water pump. He convinced authorities to stem the outbreak by disabling the pump, which researchers later discovered had been dug near a cesspit.

Dr. Kuller made significant contributions in the study of cardiovascular disease and the use of noninvasive techniques, such as ultrasound, to detect early heart disease in people without symptoms. He is also recognized for his research on the risks and prevention of cancer, as well as the study of Alzheimer’s disease.

Dr. Kuller received his medical degree from George Washington University in 1959 and completed his residency in medicine at Maimonides Hospital in Brooklyn, N.Y., in 1961. He continued his education at Johns Hopkins University School of Hygiene and Public Health, receiving a doctorate in public health in 1966 and going on to join the faculty.

In 1972, Dr. Kuller came to Pitt Public Health to chair its Department of Epidemiology, which he led for 30 years.

He has published more than 300 scientific articles, mostly in the field of epidemiology, and was recognized in a recent Thomson Reuters list as one of the most highly cited researchers worldwide.

Datasets Used by Policymakers, Scientists for Public Health Analyses Inconsistent

PITTSBURGH, Nov. 17, 2014 – Commercially available datasets containing a wealth of information about food and alcohol establishments differ significantly, raising concerns about their reliability as sources of information that could be used to set public policy or conduct scientific research, according to a University of Pittsburgh Graduate School of Public Health investigation.

The analysis, funded by the Aetna Foundation, will be presented Monday at the American Public Health Association’s (APHA) annual meeting in New Orleans. It examined systematic differences in two commercially available datasets when they were used to determine the relationship between neighborhood socioeconomic characteristics and the density of food and alcohol establishments.

“If we’re making decisions about setting public policy to improve public health – such as incentives for grocery stores that offer fresh produce in economically depressed areas – then we need to be making these decisions based on accurate data to back up the need for such incentives,” said lead investigator Dara Mendez, Ph.D., M.P.H., an epidemiologist at Pitt Public Health. “Our study found that relying on just one of these commercially available datasets likely wouldn’t provide robust information.”

There are numerous datasets available for a fee that give detailed information about food and alcohol establishments across the U.S. Typically, these datasets are purchased by companies that use them for marketing purposes.

Dr. Mendez and her team used two different commercially available datasets containing information about food and alcohol establishments in Allegheny County, which includes Pittsburgh. The information was divided into the 416 distinct census tracts in the county as a means to define neighborhoods. Each census tract consists of an average of 4,000 people.

Both of the datasets showed that the density of alcohol outlets increased as neighborhood poverty increased. However, the datasets differed when it came to grocery stores. One showed that as poverty increased, the number of grocery stores increased. The other showed no association.

“This is a perplexing disagreement that likely comes down to the datasets using different classification systems and also not accurately capturing all the information. For example, because we are familiar with Allegheny County, my team was able to determine that some of the key grocery stores in our area were not included,” said Dr. Mendez. “However, if we were doing a similar analysis for a city we were not familiar with, we likely wouldn’t catch the discrepancy and could come to an inaccurate conclusion.”

The Aetna Foundation funded the study as part of a larger grant to Pitt Public Health to study the potential influence of living in stressful neighborhoods on the health of African-American mothers and their babies.

Additional researchers on this study include Anthony Fabio, Ph.D., M.P.H., and Kevin H. Kim, Ph.D., both of Pitt; and Cecily Hardaway, Ph.D., of Duke University.

APHA Abstract No. 302593, “Examining systematic biases in secondary commercial data sources of food and alcohol environments: Differences across neighborhood racial and socioeconomic characteristics,” will be given as an oral presentation at 12:30 p.m. CST on Monday, Nov. 17, 2014.

Cyber Dating Abuse Common Among Teens, Children’s Hospital of Pittsburgh of UPMC Study Finds

PITTSBURGH, Nov. 17, 2014 – Two in five teens surveyed experienced cyber dating abuse, which involves the use of technology to control, harass, threaten or stalk another person in the context of a dating relationship, in the previous three months, according to a Children’s Hospital of Pittsburgh of UPMC study that appears online today in Pediatrics.

The study is the first about cyber dating abuse among a group of young people who are using school-based health services, said senior investigator Elizabeth Miller, M.D., Ph.D., chief, Division of Adolescent and Young Adult Medicine at Children’s Hospital.

Done in collaboration with the California Adolescent Health Collaborative of the Public Health Institute, California School-Based Health Alliance and Futures Without Violence, the study was conducted at eight school-based health centers in California where students receive confidential clinical health services, including annual check-ups, sports physicals and birth control. The study, conducted during the 2012-2013 school year, assessed teens ages 14 to 19, for exposure to cyber dating abuse, adolescent relationship abuse, sexual behavior, and care-seeking for sexual and reproductive health.

Key findings showed 41 percent of teens reported experiencing this form of abuse within the last three months, with more females than males reporting such victimization. Most commonly, their partners used technology including mobile apps, social networks, texts, or other digital communication to repeatedly contact them to see where they were and who they were with.

“These findings underscore that cyber dating abuse is an emerging concern,” said Dr. Miller, also an associate professor of pediatrics, University of Pittsburgh School of Medicine. “We need to support prevention efforts that increase education about the many different forms of abuse in adolescent relationships, and to encourage parents, teachers, coaches and others to talk to young people about what healthy relationships look like.”

Like previous research examining this form of abuse, the researchers found that teens exposed to cyber dating abuse were more likely to also experience other forms of physical and sexual dating abuse, such as being slapped, choked or made to have sex by a dating partner, and also non-partner sexual assault. Additionally, greater exposure to cyber dating abuse was associated with less contraceptive use among adolescent girls.

“It is concerning to see such a large number of young people reporting these cyber dating abuse experiences, and to learn that experiencing this form of abuse is associated with other unhealthy behaviors such as not using any method of contraception for birth control,” said Rebecca Dick, MS, clinical research coordinator, Division of Adolescent and Young Adult Medicine at Children’s, and the first author of the study.

“Professionals should take cyber dating abuse seriously and actively ask teens if they are being monitored, threatened or sexually coerced by their partner using technology-based communication,” added Dr. Miller. “Given the prevalence of cyber dating abuse in this sample of adolescents, we recommend that relationship abuse prevention education include cyber dating abuse and that such education and counseling be integrated into health assessments in clinical settings.”

Collaborators with Dr. Miller on the study were: Rebecca Dick, MS, Heather L. McCauley, Sc.D., Kelley Jones, MPH, all with Children’s Hospital of Pittsburgh of UPMC; Daniel J. Tancredi, Ph.D., University of California Davis School of Medicine; Sandi Goldstein, MPH, Alison Chopel, DrPH, California Adolescent Health Collaborative, Public Health Institute; Samantha Blackburn, RN, MSN, PNP, California School-Based Health Alliance and California State University Sacramento School of Nursing; Erica Monasterio, RN, MN, FNP-BC, University of California San Francisco School of Nursing; Lisa James, MS, Futures Without Violence; and Jay G. Silverman, Ph.D., University of California, San Diego School of Medicine.

The study was supported by Award No. 2011-MU-MU-0023, awarded by the National Institute of Justice, Office of Justice Programs, U.S. Department of Justice.

For more information on Dr. Miller and the Division of Adolescent and Young Adult Medicine, visit www.chp.edu/CHP/am.

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