The UPMC Heart and Vascular Institute and UPMC Cardiothoracic Transplant Department will be well-represented at the International Society for Heart and Lung Transplantation (ISHLT) 37th Annual Meeting and Scientific Sessions in San Diego, Ca. Faculty research will be featured in both oral and poster presentations throughout the conference, including:

 

Tuesday, April 4

ACAD Core ID – ISHLT Academy: Core Competency Course in Infectious Diseases in Thoracic Transplantation and Mechanical Circulatory Support

SESSION 2: This Could Happen to You…Drug Interactions and Toxicity Errors to Avoid with Anti-infectives and Immunosuppression and Cracking the Therapeutic Drug Monitoring Code

Presented by: Christopher R. Ensor

 

Wednesday, April 5

Opening Plenary Session

Co-Chair: Jeffrey J. Teuteberg

 

Symposium: When Should We Call It Quits? The Efficacy of Interventions to Ameliorate Psychosocial Risk Factors

When Do We Call It Quits: Intervention Strategies and Outcomes for Medical Non-Adherence

Presented by: Mary Amanda Dew

 

Are All Substances Made Equal?

Presented by: Andrea DiMartini

 

Oral Session: Cutting Edge Updates in Infectious Diseases

0039 – Clinical Risk Factors for Invasive Aspergillosis in Lung Transplant Recipients: Results of an International Cohort Study

Presented by: C. Aguilar, B. Hamandi, C. Fegbeutel, F. P. Silveira, E. A. Verschuuren, P. Ussetti, P. V. Chin-Hong, A. Sole, C. Holmes-Liew, E. M. Billaud, P. A. Grossi, O. Manuel, D. J. Levine, R. G. Barbers, D. Hadjiliadis, L. Singer, S. Husain

 

Oral Session: Bugs and Devices: A Bad Combination

0047 – Epidemiology of Fungal Infections (FI) in Mechanical Circulatory Support Device (MCSD) Recipients: Analysis of IMACS Registry 2013-2015

Presented by: O. Morrissey, R. Xie, J. Schaenman, S. Husain, M. Mooney, T. Nakatani, R. Kormos, M. Gómez-Bueno, S. Aslam, Y. Pya, M. Hannan

 

Symposium: Thinking Outside the Box: Extra-Pulmonary Management in Lung Transplantation

New Lungs – Old Sinuses: Friends or Foes?

Presented by: Joseph M. Pilewski

 

Mini Oral Session: Allocation, Bridging and Lung Allograft Assessment Strategies

0116 – Mechanical Ventilation and Extracorporeal Membrane Oxygenation (ECMO) as a Combined Bridging Strategy to Lung Transplantation: Significant Gains in Survival

Presented by: A. L. Du, J. Hayanga, J. D’Cunha, M. Tuft, M. Morrell, N. Shigemura

 

Mini Oral Session: The Hardware of MCS

0131 – Association Between the Use of Invasive Hemodynamic Monitoring and Outcomes with Percutaneous Left Ventricular Support: A Call for Standardization?

Presented by: J. J. Teuteberg, W. O’Neill

 

0132 – Analysis of Right Ventricular (RV) Regional and Global Systolic Function by Gated Blood Pool SPECT (GBPS) in Patients Undergoing Left Ventricular Assist Device (LVAD) Implantation

Presented by: C. B. Link, A. Nayak, P. Soman, M. A. Simon, J. J. Teuteberg, L. Lagazzi, A. Althouse, R. Kormos.

 

Poster Session 1: Heart Failure

0563 – Does Heart Failure with a Lower Ejection Fraction Mean Higher Costs? Insights from Data Analytics Across a Large Health Care System

Presented by: C. B. Link, S. Koscumb, P. Lynch, R. Ramani, M. Shullo, O. Marroquin, J. J. Teuteberg

 

0570 – Utilizing Data Analytics to Identify Patients at Highest Risk of Heart Failure Readmission

Presented by: C. B. Link, S. Koscumb, P. Lynch, R. Ramani, M. A. Shullo, O. Marroquin, J. J. Teuteberg

 

Poster Session 1: Junior Faculty Clinical Case Reports

0832 – Complications Following Lung Transplantation in a Patient with Short Telomere Syndrome

Presented by: C. Naik, M. Morrell

 

0847 – Successful Resolution of Refractory Rejection with Cyclophosphamide in a Lung Transplant Recipient Intolerant to Cell Cycle and Proliferation Signal Inhibitors

Presented by: C. A. Moore, M. R. Pipeling, C. R. Ensor

 

0865 – Pay Me Now or Pay Me Later: A Tale of Two Sensitized Pediatric Heart Transplant Candidates

Presented by: M. Mangiola, B. Feingold, D. Magnetta, S. West, S. Miller, M. Zinn, M. Marrari, A. Zeevi

 

Thursday, April 6

Sunrise Symposium: “Those Darn CARVs”: Community Acquired Respiratory Viruses in Lung Transplant

In the Pipeline: Novel Therapeutics

Presented by: Christopher Ensor

 

Symposium: Antibodies in Mechanical Circulatory Support: The Phantom Menace

Epidemiology and Risk of the Sensitized MCS Patient

Presented by: Michael Shullo

 

Symposium: Taming of the Shrew: Mycobacterium Abscessus in Lung Transplantation

Management of M. Abscessus in the Lung Transplant Candidate: Preparation for Transplantation

Presented by: Fernanda Silveira

 

Symposium: HLA, AMR and DSA – Approaching Antibodies in Kids

Before Transplant: Why the PRA Doesn’t Matter Anymore

Presented by: Brian Feingold

 

0225 – Neopterin Elevation and Survival Following Left Ventricular Assist Device Implantation

Presented by: M. M. Lander, M. Mercurio, K. Hanley-Yanez, M. S. Sharbaugh, A. D. Althouse, M. A. Simon, J. J. Teuteberg, L. Lagazzi, C. M. Sciortino, C. McTiernan, R. Kormos, D. M. McNamara

 

Oral Session: Contemporary LVAD Trials – Same Old Song or New Tune?

0150 – ENDURANCE Destination Therapy Trial Outcomes as Stratified by Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) Classification

Presented by: S. V. Pamboukian, F. D. Pagani, J. J. Teuteberg, R. L. Kormos, C. C. Caldeira, C. H. Selzmann, J. K. Kirklin, B. B. Reid, E. C. McGee, C. A. Milano, J. G. Rogers

 

Oral Session: Contemporary Challenges in Pediatric Heart Transplant

0182 – Impact of Newly Detected Donor Specific Anti-HLA Antibody in the First Year After Pediatric Heart Transplantation

Presented by: A. I. Dipchand, S. Webber, K. Much, B. Feingold, C. Bentlejewski, E. D. Blume, R. Shaddy, C. Canter, J. Lamour, W. Mahle, W. Zuckerman, H. Diop, Y. Morrison, B. Armstrong, D. Ikle, J. Odim, A. Zeevi

 

Mini Oral Session: Novel Strategies and Mechanisms in Lung Preservation, Heart Failure and Assist Devices

0215 – Microvasculature Analysis Using Micro CTA Techniques for Lungs After Different Preservation Process

Presented by: S. Tane, K. Noda, A. J. Hayanga, J. D’Cunha, J. D. Luketich, N. Shigemura

 

Poster Session 2: Lung Transplantation

Poster Discussant: Christopher R. Ensor

 

0988 – A Prophylaxis-Free, Pre-Emptive Approach to the Management of CMV After Lung Transplantation: Single Center Results

Presented by: A. Bertani, P. Vitulo, A. Mularoni, P. Grossi, L. De Monte, E. Russo, M. Beretta, L. Martino, A. Callari

 

Poster Session 2: Nursing, Health Sciences, Allied Health

Poster Discussant: Annette J. Devito Dabbs

 

Friday, April 7

Sunrise Symposium: Contrasts and Similarities in Children and Adults: IPAH, Portopulmonary Hypertension, and Perioperative Management

Co-Chair: Brian Feingold

 

Symposium: Dealing with Antibodies Before and After Heart Transplant

Co-chair: Michael Shullo

 

Symposium: E-Health, Wearables, Social Media and Big Data in Transplantation: Fancy Toys or True Care Innovations?

The Importance of Involving End-Users When Designing Interactive Health Technology Applications for Self-Management Support

Presented by: Annette Devito Dabbs

 

New Ethical and Legal Challenges Surrounding E-health in Transplantation

Presented by: JiYeon Choi, PhD, RN

 

Oral Session: New and Improving? Evolving Outcomes with MCS

0266 – Which INTERMACS 4-7 Patients Are at Low Risk for Mortality at One Year? Insights from the INTERMACS Database

Presented by: J. J. Teuteberg, A. D. Althouse, M. Shullo, N. Kunz, K. Lockard, E. Dunn, L. Lagazzi, C. Sciortino, J. Cowger, S. Joseph, R. L. Kormos

 

Oral Session: Saved by the Bell: Overcoming Adherence and Frailty

0331 – A Trajectory Analysis of Adherence to Recommended Exercise Following Lung Transplantation

Presented by: M. Alrawashdeh, J. Choi, A. DeVito Dabbs

 

Oral Session: PATH to Better Outcomes: Diagnostics in Heart and Lung Transplantation

0346 – Late Graft Dysfunction After Pediatric Heart Transplantation Is Associated with Fibrosis and Decreased Capillary Density by Automated, Whole-Slide Imaging

Presented by: B. Feingold, J. Picarsic, A. Lesniak, M. Wood-Trageser, B. Popp, A. J. Demetris

 

Oral Session: Heart Failure in MCS

0355 – The Duration of Inotropic Support and Survival After Left Ventricular Assist Device

Presented by: E. Grandin, D. Mooney, K. Kennedy, M. S. Kiernan, R. D. Kociol, J. J. Teuteberg, F. D. Pagani, A. C. Gaffey, P. Atluri, E. Y. Birati, S. Myers, D. Naftel, G. Oliveira, K. E. Simpson, R. W. Yeh, J. K. Kirklin, R. L. Kormos, J. Rame

 

0356 – The Incidence of Early and Late Clinical Right Heart Failure and the Impact on Survival After Continuous Flow Mechanical Support: Insights from the New INTERMACS Definition of Right Heart Failure

Presented by: J. J. Teuteberg, G. Studdard, F. Pagani, M. Kiernan, G. Oliveria, E. Rame, P. Alturi, A. Gaffey, E. W. Grandin, J. Kirlin, S. Myers, C. Collum, R. L. Kormos

 

Mini Oral Session: Pediatric Heart Failure, MCS, and Peri-Transplant Issues

0416 – Post-Transplant Outcomes of Patients Supported with the Berlin Heart EXCOR as a Bridge to Transplantation: A Multi-Institutional Study

Presented by: A. Jeewa, M. Imamura, C. Canter, R. Niebler, C. VanderPluym, D. Rosenthal, J. K. Kirklin, M. Tresler, M. McMullan, V. Morell, M. Turrentine, R. Amedur1, K. Nguyen, K. Kanter, J. Conway, R. Gajarski, C. D. Fraser Jr

 

Mini Oral Session: Assessing and Managing the Failing Right Ventricle

0434 – Painting Profiles of Ambulatory Advanced Heart Failure: A Report from the REVIVAL Registry

Presented by: M. M. Kittleson, P. Shah, A. Lala, R. McLean, S. Pamboukian, D. Horstmanshof, J. Thibodeau, K. Shah, D. Lanfear, J. Teuteberg, W. Taddei-Peters, S. Khalatbari, L. Stevenson, D. Mann, K. Aaronson, G. Stewart

 

Mini Oral Session: Patient Centered Outcomes in Advanced Heart and Lung Disease

0456 – Most Survivors Are Glad to Have a VAD

Presented by: L. W. Stevenson, J. Lindenfeld, K. Grady, J. Vader, M. Givertz, D. Naftel, T. Baldwin, S. Myers, R. Kormos, J. K. Kirklin

 

0457 – Slower Gait Speed as a Measure of Frailty Tracks with INTERMACS Profiles, Quality of Life and Predicted Mortality in Ambulatory Patients with Advanced Heart Failure: A Report from the REVIVAL Registry

Presented by: A. Lala, A. Ambardekar, J. Estep, J. Stehlik, M. Mountis, D. Haas, D. Horstmanshof, J. Thibodeau, K. Shah, D. Lanfear, J. Teuteberg, W. Taddei-Peters, S. Khalatbari, L. Stevenson, D. Mann, K. Aaronson, G. Stewart

 

Poster Session 3: Basic Science & Translational Research

1147 – Pyroptosis of Passenger Leukocytes Negatively Impacts the Quality of Lung Grafts During Ex Vivo Lung Perfusion

Presented by: K. Noda, S. Tane, A. J. Hayanga, J. D’Cunha, J. D. Luketich, N. Shigemura

 

1151 – Optimal Perfusate Oxygenation During Ex Vivo Lung Perfusion Can Promote Alveolar Proliferation in Lung Grafts

Presented by: K. Noda, S. Tane, A. J. Hayanga, J. D’Cunha, J. D. Luketich, N. Shigemura

 

1154 – DUAL Ex Vivo Lung Perfusion Techniques Can Contribute to Better Posttransplant Outcomes Through Reconditioning Hypoxic Cells in Lung Grafts

Presented by: K. Noda, S. Tane, A. J. Hayanga, J. D’Cunha, J. D. Luketich, N. Shigemura

 

1155 – ST266 Improves Oxygenation and Reduces Tissue Injury in an In-Situ Rat Left Lung Ischemia-Reperfusion Model

Presented by: C. F. Evans, X. Wang, X. Liu, R. Mishra, V. Mishra, S. Rahimpour, A. Zeevi, R. Banas, S. M. Pham

 

1160 – Bronchial Artery Sparing Lung Preservation: Is It Feasible?

Presented by: S. Tane, K. Noda, A. J. Hayanga, J. D’Cunha, J. D. Luketich, N. Shigemura

 

1161 – Nitrite Improves Mitochondrial Dysfunction Induced by Hypoxia/Reoxygenation in Lung Epithelial Cells: Implications for Ischemia-Reperfusion (I/R) Injury in Lung Transplantation

Presented by: A. Kumar, C. Corey, S. Shiva, M. T. Gladwin, J. D’Cunha

 

Poster Session 3: Heart Transplantation

1192 – Informative and Uninformative Variables in the Scientific Registry of Transplant Recipients

Presented by: E. M. Hsich, L. Thuita, D. McNamara, J. G. Rogers, J. Schold, E. H. Blackstone, H. Ishwaran

 

Poster Session 3: Lung Transplantation

1244 – Systematic Review and Meta-Analysis of Death After Posttransplant Lymphoproliferative Disease in Lung Transplantation

Presented by: C. A. Moore, J. Cheng, C. J. Iasella, A. R. Glanville, M. R. Morrell, R. B. Smith, J. Hayanga, J. F. McDyer, C. R. Ensor

 

1255 – Successful Maintenance Belatacept-Based Immunosuppression in Lung Transplantation Recipients Who Failed Calcineurin Inhibitors

Presented by: C. J. Iasella, R. J. Winstead, C. A. Moore, B. A. Johnson, M. R. Morrell, J. Hayanga, A. Zeevi, E. A. Lendermon, J. F. McDyer, C. R. Ensor

 

1263 – Increasing Tacrolimus Time-in-Therapeutic Range Is Associated with Reduced Chronic Lung Allograft Dysfunction

Presented by: C. A. Moore, K. M. Harrigan, C. J. Iasella, R. Venkataramanan, M. R. Morrell, J. Hayanga, J. D’Cunha, A. Zeevi, J. McDyer, C. R. Ensor

 

Poster Session 3: Mechanical Circulatory Support

1303 – Pre-Implant Under-Expression of CCR3 and Its Ligands Predicts One-Year Mortality in Left Ventricular Assist Device Patients

Presented by: A. Nayak, C. Neill, R. L. Kormos, L. Lagazzi, I. Halder, C. McTiernan, J. Larsen, A. Inashvili, J. Teuteberg, T. N. Bachman, K. Hanley-Yanez, D. M. McNamara, M. A. Simon

 

Saturday, April 8

Sunrise Symposium: Mechanical Circulatory Support – The Interface of Design and Outcome

Co-chair: R. Kormos

 

Sunrise Symposium: Extracorporeal Photopheresis: Shedding Light on Rejection?

Co-Chair: Matthew R. Morrell

 

Plenary Session 3

0496 – Advanced Therapy Utilization and Survival in Ambulatory Patients with Advanced Heart Failure: Results from the Medical Arm of Mechanically Assisted Circulatory Support (MedaMACS) Registry

Presented by: A. V. Ambardekar, M. Kittleson, M. Palardy, M. Mountis, R. Forde-McLean, A. DeVore, S. Pamboukian, J. Thibodeau, J. Teuteberg, L. Cadaret, R. Xie, L. Stevenson, G. Stewart

 

Oral Session: Not the Usual Suspects: Driving Outcomes in MCS

0500 – Temporal Patterns of Adverse Events (AE) Occurring within 60 Days of LVAD Implantation: The Concept of the AE Cascade

Presented by: J. O. Larsen, A. D. Althouse, J. J. Teuteberg, C. M. Sciortino, C. V. Nikas, L. F. Lagazzi, M. S. Sharbaugh, S. U. Iturra, N. M. Kunz, E. M. Dunn, K. L. Lockard, R. L. Kormos

 

Oral Session: Seeing the Patient Beyond the Device

0504 – Glad to Have a VAD Across Intermacs Profiles

Presented by: F. Pagani, M. Kittleson, G. Stewart, A. DeVore, M. Brinkley, S. Myers, M. Miller, D. Naftel, J. J. Teuteberg, L. W. Stevenson

 

Oral Session: Getting to the Heart of the Matter: Psychosocial Predict Outcomes in Transplant and MCS

0243 – Social and Clinical Characteristics Associated with Increased Short Term Mortality in Non-Inotrope Dependent Patients Undergoing Left Ventricular Assist Device Therapy: Results from InterMACS

S. M. Joseph, R. L. Kormos, J. Teuteberg, A. Althouse, J. Cowger.

 

Oral Session: The Weighting Game: Impact of Obesity, Age, and Other Comorbidities in MCS

0471 – Adverse Events After Device Implantation Are More Common in Obese Patients: An IMACS Registry Analysis

Presented by: S. J. Forest, R. Xie, J. K. Kirklin, J. A. Cowger, Y. Xia, A. I. Dipchand, C. Sivathasan, C. Merry, L. H. Lund, R. Kormos, T. Nakatani, U. Jorde, D. J. Goldstein

 

Oral Session: Optimizing Early Outcomes after Lung Transplantation

0482 – Treatment of Antibody Mediated Rejection of the Lung Allograft with Carfilzomib-Based Therapy

Presented by: C. R. Ensor, A. Zeevi, S. A. Yousem, M. Mangiola, M. Marrari, M. R. Morrell, J. M. Pilewski, J. D’Cunha, J. F. McDyer

 

Oral Session: Influencing Long-term Outcomes in Lung Transplantation

0516 – Regulation of KLRG1 Gene Expression by T-bet Correlates with Human Cytomegalovirus-Specific CD8+ T Cells Effector Function

Presented by: A. Hoji, I. Popescu, M. Pipeling, H. Mannem, J. McDyer