UPMC Physician Resources

Archives for Pediatrics

Neuro-Oncology Researcher at Children’s Hospital of Pittsburgh of UPMC Receives Grant from St. Baldrick’s Foundation

PrintGary Kohanbash, PhD, a neuro-oncology researcher at Children’s Hospital of Pittsburgh of UPMC, has been awarded a scholar grant of $298,000 from the St. Baldrick’s Foundation, a volunteer-driven charity dedicated to raising money for childhood cancer research.

These grants provide resources to institutions to conduct more research and enroll more children in ongoing clinical trials. Kohanbash and his team will look at improving immunotherapy for ependymomas, the third most common kind of brain tumor in children.

“As a scientist and a father, I am driven to help save kids from brain cancers, so I am very excited about the potential of immunotherapy. Unimaginable advances within the last 10 years are enabling us to create new, safer and more effective treatments,” said Kohanbash, who also is an assistant professor of neurological surgery at the University of Pittsburgh School of Medicine. “With this funding from the St. Baldrick’s Foundation, I am hopeful that we can bridge the gap between lab research and clinical care for kids with ependymomas.”

Kohanbash’s team has identified three peptides that might activate immune cells to specifically fight one of the more lethal types of ependymoma. He will be testing these peptides in the lab and also is looking at how immunotherapy could help fight all six types of ependymoma that affect kids.

“We are thrilled Dr. Kohanbash is receiving this grant based on his experience and accomplishments in the field of brain tumor immunology and his ongoing work to translate findings from the lab into promising treatments for children with ependymomas,” said Ian Pollack, MD, chief, Pediatric Neurosurgery, Children’s Hospital.

The grant is supported by the St. Baldrick’s Henry Cermak Fund for Pediatric Cancer Research.

For more information, please visit www.chp.edu.

Children’s Hospital of Pittsburgh of UPMC Ranked Among Top Pediatric Hospitals in the United States

Children’s Hospital of Pittsburgh of UPMC has once again been recognized as one of the top pediatric hospitals in the country, earning a spot on this year’s U.S. News & World Report Honor Roll of America’s Best Children’s Hospitals.

It is the 8th consecutive year Children’s Hospital has appeared on the Best Children’s Hospitals list, which was released today.

“We are proud to be consistently recognized as one of the best children’s hospitals in the country,” said Christopher Gessner, president, Children’s Hospital. “It is rewarding for our physicians, nurses and support staff, who every day work together with skill and passion to provide the best care for children and adolescents with the most complex medical conditions.”

The Best Children’s Hospitals rankings highlight the top 50 US pediatric hospitals in each of 10 specialties: cancer; cardiology and heart surgery; diabetes and endocrinology; gastroenterology and GI surgery; neonatology; nephrology; neurology and neurosurgery; orthopedics; pulmonology; and urology.

Children’s is ranked 9th on the honor roll and is ranked in all 10 of the specialties.

The 2017-18 Best Children’s Hospitals rankings will be released online today and will be published in the “Best Hospitals 2018” guidebook, available in September.

The Best Children’s Hospitals rankings were introduced in 2007 to help families of children with rare or life-threatening illnesses find the best medical care available. The rankings open the door to an array of detailed information about each hospital’s performance.

The other hospitals named to the Honor Roll of Best Children’s Hospitals for 2017-18 are:

1. Boston Children’s Hospital
2. Children’s Hospital of Philadelphia
3. Cincinnati Children’s Hospital Medical Center
4. Texas Children’s Hospital, Houston
5. John Hopkins Children’s Center, Baltimore
6. Children’s Hospital Los Angeles
7. Ann and Robert H. Lurie Children’s Hospital of Chicago
7. Nationwide Children’s Hospital, Columbus, Ohio
9. Children’s Hospital of Pittsburgh of UPMC
10. Children’s National Medical Center, Washington D.C.

Children’s Hospital of Pittsburgh of UPMC Pulmonary Chief Elected Secretary-Treasurer of the American Thoracic Society

CELEDON_JUAN_MD_PDP_20131105_CSThe American Thoracic Society (ATS) has elected Juan C. Celedón, MD, DrPH, chief, Division of Pulmonary Medicine, Allergy and Immunology at Children’s Hospital of Pittsburgh of UPMC, as its Secretary–Treasurer for the 2017–18 term.
Dr. Celedón will then assume the role of ATS President for the 2020 21 term and notably will be the first ATS president from the University of Pittsburgh, as well as the first Latino American to serve as ATS president, in the 115-year history of the society.

“I am deeply humbled and honored to have been elected as the Secretary-Treasurer of the American Thoracic Society, arguably the leading professional society in academic pulmonary, critical care and sleep medicine worldwide,” said Dr. Celedón, Niels K. Jerne Professor of Pediatrics, University of Pittsburgh School of Medicine. “I hope to further the mission of the ATS in achieving respiratory health equality and workforce diversity, while continuing to pursue excellence in research, education and training, as well as clinical care of patients with pulmonary diseases, critical illnesses and sleep disorders.”

“On behalf of the ATS community, we wholeheartedly welcome Dr. Celedón to the elected leadership of the Society,” said David Gozal, MD, MBA, president of the ATS. “His previous achievements and recognition have clearly earned him this honor. We look forward to his future contributions to the ATS and to the field of pulmonary, critical care and sleep medicine both nationally and around the world.”

Dr. Celedón has been a member of the ATS since 1993. He received from the ATS the “Recognition Award for Scientific Accomplishments” in 2014, and was the first-ever recipient of the “Lifetime Award for Innovations in Health Equality” in 2015.

His research has focused on asthma and COPD, and on health disparities in airway diseases. His research, which has been funded by the National Institutes of Health, has been recognized with his election to the American Society for Clinical Investigation and the Association of American Physicians.

Dr. Celedón, who also serves as professor of Medicine, Epidemiology and Human Genetics at the University of Pittsburgh, will be installed as Secretary–Treasurer in May at the ATS 2017 International Conference in Washington, DC.

Founded in 1905, the American Thoracic Society is the world’s leading medical association dedicated to advancing pulmonary, critical care and sleep medicine. The Society’s 15,000 members prevent and fight respiratory disease around the globe through research, education, patient care and advocacy. The ATS publishes three journals, the American Journal of Respiratory and Critical Care Medicine, the American Journal of Respiratory Cell and Molecular Biology and the Annals of the American Thoracic Society.

For more information on Dr. Celedón, visit www.chp.edu.

Announcing Our New Co-Director of the Inflammatory Bowel Disease (IBD) Center — Sandra Kim, MD, Children’s Hospital of Pittsburgh of UPMC

PrintSandra Kim, MD, a nationally recognized expert in pediatric and adolescent inflammatory bowel disease, is the co-director of the Inflammatory Bowel Disease (IBD) Center, a part of the Division of Pediatric Gastroenterology, Hepatology, and Nutrition at Children’s Hospital of Pittsburgh of UPMC. Dr. Kim is also Associate Professor of Pediatrics at the University of Pittsburgh School of Medicine. Prior to joining Children’s Hospital, Dr. Kim was co-director of the Center for Pediatric and Adolescent Inflammatory Bowel Disease at Nationwide Children’s Hospital in Columbus, Ohio.

In Pittsburgh, Dr. Kim, along with Sapana Shah, MD, will establish the hospital’s participation in Improved Care Now, a national consortium to improve the care of children with IBD. Dr. Kim’s clinical and research interests focus on pediatric inflammatory bowel diseases, including adolescent transitioning and quality improvement in pediatric IBD and the impact of the gastrointestinal microbiota in IBD. Her research has been funded by the National Institutes of Health and the Crohn’s and Colitis Foundation of America (CCFA). She has authored numerous studies on pediatric and adolescent inflammatory bowel diseases. Dr. Kim currently serves as past chair of Pediatric Affairs and current co – chair of Government Affairs/Advocacy for the CCFA nationally. In addition, she chairs the Clinical Practice and Adolescent Transitioning committees and serves on the Physician Leadership committee and Strategy Council for Improve Care Now. Dr. Kim also is involved as a member of the Medical Advisory Board for Flying Horse Farms and on the board of Directors for the Central Ohio CCFA chapter. As a reflection of her dedication to her profession, Dr. Kim was awarded the 2011 Rosenthal Award for her leadership in patient education and advocacy by the CCFA. She also was the 2015 faculty inductee at the Ohio State University College of Medicine chapters of Gold Humanism Honor Society and Alpha Omega Alpha.

Dr. Kim is a graduate of the University of Michigan’s Inteflex (Integrated Pre-medical/Medical) Program, earning bachelors’ degrees in Biomedical Sciences and Psychology as well as her medical degree. She completed clinical training in General Pediatrics and Pediatric Gastroenterology at Texas Children’s Hospital and the Baylor College of Medicine. She was a recipient of the Outstanding Clinical Fellow Award during her GI fellowship and was on the NIH/NIDDK-funded T32 grant for her research project investigating zinc metabolism in children with IBD. After her clinical training, she pursued additional training as a post-doctoral fellow at the NIH-funded Center for GI Biology and Disease at the University of North Carolina at Chapel Hill.

American Academy of Pediatrics Webinar Series on Zika Virus featuring Amy Houtrow, MD, PhD — Jan. 10, 2017

Recognizing Microcephaly and Other Presentations of Zika Virus Syndrome
Tuesday, Jan. 10, 2 p.m. ET
Registration is required.

Dial-In Information
Phone: 844-216-1726
Conference ID: 18985179
Registration Link: https://cc.readytalk.com/r/viw68r9pls12&eom

Description
Over the past year, congenital Zika virus syndrome has captured the attention of the world because of the devastating effects it can have on infants’ development. In recognition that pediatricians (primary care providers, clinicians, and subspecialists) will require support and guidance, the American Academy of Pediatrics Webinar Series on Zika Virus Syndrome was created. During the first webinar in this series, expert speakers will provide an overview of the neurodevelopmental manifestations of congenital Zika virus syndrome. Experts will also describe how to monitor symptomatic and asymptomatic infants, including how to collaborate with specialists to ensure a continuum of care.

Speakers
Amy Houtrow, MD, PhD, MPH, FAAP
Dr Houtrow is pediatric rehabilitation medicine physician and health services researcher.  She is an Associate Professor and Vice Chair in the Department of Physical Medicine and Rehabilitation for Pediatric Rehabilitation Medicine at the University of Pittsburgh School of Medicine. She directs the Pediatric Rehabilitation Medicine Fellowship and is the Chief of Pediatric Rehabilitation Medicine Services and the Medical Director of the Rehabilitation Institute at the Children’s Hospital of Pittsburgh. Dr Houtrow’s main clinical focus is caring for children with disabling conditions to help to improve functioning and quality of life to the greatest degree possible. Her research focuses on improving how children with disabilities and their families access health care to optimize health care delivery.

Edwin Trevathan, MD, MPH, FAAP
Dr. Trevathan is a child neurologist, an epidemiologist, and a public health leader, who is internationally known for his expertise in childhood epilepsy, disorders of the developing brain, developmental disabilities, and birth defects. Trevathan is a Professor of Pediatrics and Neurology at Vanderbilt University School of Medicine, and a pediatric neurologist at the Monroe Carell Jr. Children’s Hospital at Vanderbilt. Dr Trevathan has held a number of senior leadership positions in academia and in government. He has served as Executive Vice President and Provost at Baylor University; Dean of the College for Public Health and Social Justice at Saint Louis University; Director of the Division of Pediatric and Developmental Neurology at Washington University in St. Louis, MO; and Director of the National Center on Birth Defects and Developmental Disabilities at the Centers for Disease Control and Prevention.

Additional Information
Please email DisasterReady@aap.org with any questions prior to the webinar.

 

 

Grant Awarded for National Biorepository for GUDMAP Biobank

Sunder Sims-Lucas, PhD, and Jacqueline Ho, MD, are co-investigators on a $600,000 per year grant for 5 years from the National Institutes of Health to be the national biorepository for the GenitoUrinary Development Molecular Anatomy Project (GUDMAP).

smis-lucas_sunder_phd_pn_20140728

 

 

 

 

ho_jacqueline_md_pn_20100818

 

 

 

 

GUDMAP is an international consortium working to generate gene expression data and transgenic mice as tools to study genitourinary development. This curated, high-resolution dataset serves as a powerful resource for biologists, clinicians and bioinformaticians interested in the developing urogenital system.

GUDMAP data is accessible at www.gudmap.org.

Hospitalized Patients at Risk if Sodium Levels are Low

Michael Moritz, MD, explains how hospitalized patients could be at risk of weak bones, and increased infections if physicians ignore low-sodium in the body, known as hyponatremia.

Dr. Moritz is clinical director, Division of Pediatric Nephrology at Children’s Hospital of UPMC and as Professor of Pediatrics at the University of Pittsburgh School of Medicine. Dr. Moritz is an authority on sodium and water metabolism in children.

Hospitalized patients at risk if sodium levels are low – Frontiers Science Hero from Frontiers on Vimeo.

Growing Kidneys in Lymph Nodes

Carl Bates, MD, and Sunder Sims-Lucas, PhD, of the Division of Pediatric Nephrology at Children’s Hospital of Pittsburgh of UPMC, in collaboration with Eric Lagasse, PhD, of the University of Pittsburgh McGowan Institute for Regenerative Medicine, are developing a novel approach to regenerate kidney tissues.

The group has discovered that embryonic kidney fragments and isolated nephron progenitors have the potential to form perfused kidney structures when injected into mouse lymph nodes. The Bates, Sims-Lucas, and Lagasse laboratories have received a Pediatric Device Initiative Award sponsored by the Commonwealth of Pennsylvania in support of their work.

 

Children’s Hospital of Pittsburgh Experts At the 30th Annual North American Cystic Fibrosis Conference

PrintThe 30th annual North American Cystic Fibrosis Conference was held October 27-29 in Orlando. The event brought scientists, clinicians, and other healthcare professionals from around the world to share the latest ideas and advances in cystic fibrosis research, drug development, and patient care, and included posters and presentations from field-leading experts.

Several Children’s Hospital of Pittsburgh of UPMC faculty and staff presented at the conference on a number of topics including:

 

Poster: Identification of Novel Inhibitors of Ubiquitination That Improve Rescue of F508DELCFTR by VX-809

Goeckeler-Fried, Jennifer; Estabrooks, Samuel K; Chiang, Annette; Chung, Wook Joon; Ye, Zhaofeng; Denny, Rajiah Aldrin; Weissman, Allan M; Camacho, Carlos J; Sorscher, Eric J; Brodsky, Jeffrey L

Poster: Recognition of CFTR By BCL2 Associated Athnaogene 3 (BAG3): A Pathway meditating Autophagic CFTR Degradation

Mishra, Sanjay K ; Frizzell, Raymond A.

Poster: Ubiquitin-Specific Proteases 11(USP11)and 28(USP28)Regulate F508DELCFTRStability Via SUMOConjugation

Gong, Xiaoyan; DaPaula ,AnaCarina; Ahner, Annette; Frizzell, Raymond A

Poster/Workshop Presentation: Predicted Phosphorylation Site in SLC26A9 Modulates CFTR-Dependent Activity

Wang, Xiaohui; Larsen, Mads B; Frizzell, Raymond A.; Bertrand, Carol A.

Poster: Pseudomonas aeruginosa Benefits From Respiratory Viral Infection in Cystic Fibrosis

Jeffrey Melvin

Poster: Viral-Bacterial Interactions in the Paranasal Sinuses in Cystic Fibrosis

Jeffrey Melvin

Abstract: Dynamics of Staphylococcus aureus growth on airway epithelial cells

Megan R Kiedrowski

Presenting: Thursday, Oct. 27 – W06: INF/MIC: Pathogenesis of Airway Infection (speaking 10:20-10:30a)

Poster Session I (11:15a-1:45p), Friday, Oct. 28 – JIB: Junior investigators best abstract session: Basic Science (12:15-1:35p)

Poster: Dysregulation of Nutritional Immunity during Respiratory Viral Infection Promotes Pseudomonas aeruginosa Biofilm Growth

Matthew Hendricks

Poster: SIRT1 Mediates Resveratrol Inhibition of CFTR In Primary Bronchial Epithelium

Agnieszka Swiatecka-Urban, MD, FASN

Poster: TGF-β1 Upregulates Microrna- 145 To Block ∆F508-CFTR Rescue

Agnieszka Swiatecka-Urban, MD, FASN

Poster: Anti-biofilm activity and in vivo efficacy of an engineered peptide antibiotic”

Berthony Deslouches

Workshop III: CLIN: *Emerging Issues in CF Lung Transplantation

A. Faro, J. Pilewski

Poster: Infection and depressed mucociliary clearance in pediatric and adult CF patients

Corcoran TE, Locke LW, Myerburg MM, Weiner DJ, Pilewski JM

Poster: Nitrogen Back Diffusion During Multiple Breath Washout With 100% Oxygen

Weiner DJ, Pederson K, Nielson JG.

Poster: Lung Function Perception in Cystic Fibrosis

Forno E, Weiner DJ

World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition 2016

PrintThe 5th World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition (WCPGHAN) was held October 5-8, 2016 in Montreal. This event showcased state of the art science and technology in the field of pediatric gastroenterology, hepatology, and nutrition, as well as presentations and keynote speeches from experts who are leaders in their field.

The conference encompassed nine themes including:

  • IBD
  • Celiac and other GI disorders
  • Neurogastroenterology and motility
  • Endoscopy
  • Hepatology
  • Pancreatology
  • Global health
  • Nutrition and intestinal rehabilitation
  • Transplantation

Several Children’s Hospital of Pittsburgh of UPMC faculty and staff spoke at the conference on a number topics including:

Immune Tolerance and Rejection
Pharmacology (pharmaco-genetics) and immunosuppression: Past, present and future
Patrick McKiernan, MD

Steatorrhea: What if it’s not Cystic Fibrosis
Mark Lowe, MD, PhD

Acute Liver Failure – Pathogenesis and Management
Rob Squires, MD and Anil Dhawan, MD

Pancreas
Mark Lowe, MD PhD

Pancreatitis

Inflammatory Responses/ Healing in Pancreatic Injury
Sohail Husain, MD

Poster Presentations

Sterile Cerebrosprinal Fluid Ascites: A Rare Complication After Ventriculoperitoneal Shunting
James Squires, MD, and  Kristen Critelli, MD (fellow)

Clinical Variability Following Partial External Biliary Diversion In Familial Intrahepatic Cholestasis 1 Deficiency
James Squires, MD,  Robert Squires, MD, and Amy Morris, RN, CCPC

Page 1 of 14:1 2 3 4 »Last »