UPMC Physician Resources

Archives for Pediatrics

New Placenta Model Could Reveal How Birth Defect-Causing Infectious Agents Cross From Mother to Baby

Researchers at the University of Pittsburgh and Magee-Womens Research Institute (MWRI) have devised a cell-based model of the human placenta that could help explain how pathogens that cause birth defects, such as Zika virus, cross from mother to unborn child. The findings were published today in Science Advances.

The placenta is a complex and poorly understood organ that anchors the developing fetus to the uterus, nourishes the baby, and provides a barrier to the spread of microorganisms from an infected mother to the fetus, explained senior investigator Carolyn Coyne, PhD, associate professor of microbiology and molecular genetics at Pitt School of Medicine and a member of the MWRI.

“The human placenta is unique and unlike that of other many other placental mammals,” she said. “With our new model in the research toolkit, we and other scientists hope to advance our knowledge of the placenta, examine its function , and learn how it can prevent most, but not all, maternal infections from causing problems for the baby.

Researchers currently can obtain and study placental cell lines, but such cells do not fuse spontaneously to form the characteristic structure of the human organ. Some scientists study cells, called primary human trophoblasts, that are isolated from placentas obtained after childbirth, but such cells do not divide, can be more difficult to obtain, and are more difficult to genetically manipulate to learn about biochemical pathways that have a role in placental function, Dr. Coyne said.

Dr. Coyne’s team took a different approach: They cultured a human placental trophoblast cell line in a microgravity bioreactor system developed by NASA. The trophoblasts along with blood vessel cells were added to small dextran beads that were then spun around in a container filled with cell culture fluid, creating shear stress and rotational forces to better mimic the environment at the maternal-fetal interface than static cell-culture systems.

As a result, the cells fused to form syncytiotrophoblasts, and thus more closely resemble the primary cells lining the outermost layer of the tree-like or villous structure of the human placental tissue. Next, the researchers tested the functional properties of their model by exposing it to a virus and to Toxoplasma gondii, a parasite found in cat feces that can lead to fetal infection, causing miscarriage, congenital disease and/or disability later in life.

“We found that the syncytiotrophoblasts formed in our system recapitulated the barrier properties of the naturally occurring cells and they resisted infection by a model virus and three genetically different strains of Toxoplasma,” said co-investigator Jon P. Boyle, PhD, associate professor of biological sciences at Pitt. “With this model, we can experiment with different biological factors to see what might allow an infectious agent to get through the placental barrier to the fetus.”

Understanding the placenta might one day lead to ways to prevent fetal damage from the so-called TORCH infections: toxoplasmosis, rubella, cytomegalovirus, herpes and HIV, he added.

The researchers are beginning to use their model to test whether Zika virus, and other pathogens associated with congenital disease, can infect placental cells and/or cross the placental barrier.

Research team members include Cameron McConkey, BS, Elizabeth Delorme-Axford, PhD, and Yoel Sadovsky, MD, all of the University of Pittsburgh; Cheryl A. Nickerson, PhD, of Arizona State University; and Kwang Sik Kim, MD, of Johns Hopkins University.

The project was funded by National Institutes of Health grants AI081759 and HD075665 and the Burroughs Wellcome Fund.

Nephrotic Syndrome Symposium

Nephrotic Syndrome: Clinical Challenges and Evidence-based Management
May 12, 2016 – 9:00 a.m. to 6 p.m.
Children’s Hospital of Pittsburgh of UPMC
4401 Penn Ave.
Pittsburgh, PA 15224

Please join us for this one day event will engage glomerular kidney disease researchers, clinicians, other healthcare professionals and patient families. This event promises to foster new collaborations, close the gaps between research and clinical care and form common research agendas.

Course Directors
Agnieszka Swiatecka-Urban, MD
Children’s Hospital of Pittsburgh of UPMC,
University of Pittsburgh School of Medicine

Hoda Kaldas, MD
University of Pittsburgh

To view the Save the Date flyer, click here.
For more information or to register, click here.

 

Chief of Hematology/Oncology at Children’s Hospital of Pittsburgh of UPMC Selected for Pediatric Cancer MoonShot Consortium

PrintLinda McAllister-Lucas, M.D., Ph.D., chief of the Division of Pediatric Hematology/Oncology at Children’s Hospital of Pittsburgh of UPMC, has been selected as a member of the prestigious Pediatric Cancer MoonShot Consortium.

The announcement was made at the Cancer MoonShot 2020 press conference held this week in Phoenix.

Dr. McAllister-Lucas is an internationally recognized expert in lymphoma whose research has provided new insights into the molecular basis of these types of cancers.

The Cancer MoonShot 2020 Program is a cancer collaborative initiative seeking to accelerate the potential of combination immunotherapy as the next-generation standard of care for cancer patients. This group aims to explore a new paradigm in cancer care by initiating randomized Phase II trials involving 20,000 patients with 20 tumor types within the next 36 months. These findings will inform Phase III trials and the aspirational “moonshot” to develop effective, vaccine-based immunotherapies to combat cancer by 2020.

The newly formed consortium will focus on bringing the promise of immunotherapy to children diagnosed with the disease. The group will seek to apply the most comprehensive diagnostic testing available—whole genomic and proteomic analysis—and leverage proven and promising combination immunotherapies and clinical trials under the QUantitative, Integrative Lifelong Trial (QUILT) Program within the Cancer MoonShot 2020 mission.

“Less than 1 percent of cancers in the United States occur in pediatric patients. And yet, the loss of years and quality of life to pediatric cancer is huge,” said Dr. McAllister-Lucas, also an associate professor of pediatrics at the University of Pittsburgh School of Medicine. “The Cancer MoonShot 2020 will pour resources into research investigating the cause, the diagnosis and the treatment of pediatric cancers. This MoonShot will start a new era of hope for our patients and their families, and will lead the way toward more effective, less toxic treatments, and higher quality, longer lives for children with cancer.”

Dr. McAllister-Lucas is one of 10 members from various academic centers across the United States to be included in the consortium. Other centers include: Ann & Robert H. Lurie Children’s Hospital of Chicago; Children’s Healthcare of Atlanta, Aflac Cancer & Blood Disorders Center; Children’s Hospital of Orange County; Children’s Hospital of Philadelphia; Duke Department of Pediatrics – Duke University School of Medicine; Floating Hospital for Children at Tufts Medical Center; Huntsman Cancer Institute at the University of Utah and Intermountain Primary Children’s Hospital; Phoenix Children’s Hospital; and Sanford Health.

The Division of Pediatric Hematology/Oncology at Children’s provides diagnosis, treatment and follow-up for children, adolescents and young adults with cancer and blood disorders. The division is the largest, most comprehensive pediatric cancer and blood disease center in western Pennsylvania, eastern Ohio and northern West Virginia and has been a member of the Children’s Oncology Group, a multi-institutional pediatric cancer research organization sponsored by the National Cancer Institute, since 1961.

For more information on Dr. McAllister-Lucas, visit www.chp.edu.

Officials Announce New Chair of Pediatrics at Pitt and Scientific Director of Children’s Hospital of Pittsburgh of UPMC

PrintTerence S. Dermody, MD, has been named the new chair of the Department of Pediatrics at the University of Pittsburgh School of Medicine and physician-in-chief and scientific director at Children’s Hospital of Pittsburgh of UPMC.

Dr. Dermody will officially begin on June 1. He joins Children’s Hospital from Vanderbilt University, where he is the Dorothy Overall Wells Professor of Pediatrics, director of the Division of Pediatric Infectious Diseases, and director of the Medical Scientist Training Program at Vanderbilt University School of Medicine. He also is a professor of pathology, microbiology and immunology at Vanderbilt.

“Terry Dermody is a world renowned researcher, compassionate physician, visionary leader and just an all-around first class person,” said Christopher Gessner, president, Children’s Hospital. “We are thrilled that he will be joining our team as we continue to grow our clinical and research programs and make Children’s the place to be for pediatric physicians and physician scientists to launch and build their careers.”

Dr. Dermody is a virologist with interests in viral pathogenesis and vaccine development. He has focused mainly on reovirus, an important experimental model for studies of viral encephalitis in infants, and on chikungunya virus, an arthropod-borne virus that causes epidemics of febrile arthritis.

The work in Dr. Dermody’s lab has encompassed several inter-related themes including the structural basis of viral attachment and cell entry, mechanisms of genome replication and packaging, patterns of cell signaling and gene expression occurring in response to viral infection, mechanisms of virus-induced apoptosis and its significance in the viral life cycle, and the role of viral receptor distribution and utilization in disease pathology. Currently, the lab is developing viral vectors for oncolytic and vaccine applications.

“Dr. Dermody came highly recommended by leaders in our Department of Pediatrics,” noted Arthur S. Levine, M.D., senior vice chancellor for the health sciences and John and Gertrude Petersen Dean of Medicine, University of Pittsburgh. “His academic interests, which included running Vanderbilt’s M.D./Ph.D. training program, are unusually broad. An exceptional physician and scientist, he will be an asset to our faculty, residents and students.”

“I am honored to be able to join the team in Pittsburgh and be a part of this world-class pediatric facility dedicated to improving the lives of children,” said Dr. Dermody. “I am eager to begin and have the opportunity to work with the talented physicians and scientists at Children’s Hospital. I feel honored and humbled to have this opportunity.”

Dr. Dermody succeeds David H. Perlmutter, M.D., who recently left Children’s to become executive vice chancellor for medical affairs and dean of medicine at Washington University in St. Louis.

Dr. Dermody received his bachelor’s degree from Cornell University in 1978, and his medical degree from Columbia University in 1982. He completed an internal medicine residency at Presbyterian Hospital in New York in 1985 and fellowships in infectious diseases and molecular virology at Brigham and Women’s Hospital and Harvard Medical School in 1988.

He has authored or co-authored more than 200 articles, reviews and chapters about his research, which is supported by grants from the National Institutes of Health (NIH) and the Lamb Foundation. He currently holds five NIH grants, and his research has been continually funded by the NIH since 1987.

He has been recognized for his research accomplishments with the Ernest W. Goodpasture Faculty Research Award, the Grant W. Liddle Award for Leadership in the Promotion of Scientific Research, and an NIH MERIT Award. He is a past president of the American Society for Virology, past chair of the AAMC GREAT Group M.D./Ph.D. Section Steering Committee, and current chair of the Virology Division of the International Union of Microbiological Societies.

For more information on Dr. Dermody and Children’s Hospital of Pittsburgh of UPMC, visit www.chp.edu.

- See more at: http://www.chp.edu/news/011116-new-pediatrics-chair#sthash.Wr8mpdQv.dpuf

Children’s Hospital of Pittsburgh of UPMC Gastroenterologist Receives Prestigious Murray Davidson Award

PrintThe American Academy of Pediatrics (AAP) has awarded Robert H. Squires, M.D., director of pediatric hepatology, a program of the Division of Pediatric Gastroenterology, Hepatology, and Nutrition at Children’s Hospital of Pittsburgh of UPMC, its 2015 Murray Davidson Award. The award was presented on Oct. 9 at the annual meeting of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) in Washington, D.C.

The award recognizes an outstanding clinician, educator and scientist who has made significant contributions to the field of pediatric gastroenterology, hepatology and nutrition.

“I am humbled that my colleagues consider me to be deserving of an award that includes my heroes in the field of pediatric gastroenterology, hepatology and nutrition,” said Dr. Squires, also professor of pediatrics at the University of Pittsburgh School of Medicine. “While given to an individual, this very special award is a testament to my fortunate encounters with strong mentors, colleagues and patients; and to my wonderfully supportive and accomplished family.”

Dr. Squires is the principal investigator for the multi-center, multi-national National Institutes of Health-sponsored pediatric acute liver failure study group; the site principal investigator for the Childhood Liver Disease Research Network; and was the principal investigator for the Pediatric Intestinal Failure Consortium.

“Dr. Squires embodies the qualities celebrated by the Murray Davidson Award,” said Mark E. Lowe, M.D., Ph.D., director, pediatric gastroenterology, hepatology and nutrition, Children’s Hospital. “I can’t think of a more deserving awardee. We are fortunate to have him helping care for the children of western Pennsylvania.”

Dr. Squires served as chair of the AAP Section on Gastroenterology, Hepatology and Nutrition and was an executive council member of NASPGHAN. He has published over 70 peer-reviewed articles in major journals, 47 in the past 10 years.

“Dr. Squires is a physician with a stable internal compass that has always directed him to serve the health care needs of children in the broadest sense,” said David Keljo, M.D., Ph.D., director, Inflammatory Bowel Disease Center, Children’s Hospital. “He has consistently worked to ensure the best possible clinical care for children, displaying great character while leading the way. It was a privilege to nominate him.”

The Division of Pediatric Gastroenterology, Hepatology and Nutrition at Children’s is ranked second in the country by U.S. News & World Report’s 2015-16 Best Children’s Hospital specialty ranking for pediatric gastroenterology and GI surgery. The division consists of experts in general clinical pediatric gastroenterology, pediatric hepatology, and a broad range of specialty areas, including abdominal pain, acute and chronic pancreatitis, constipation, diarrhea, eosinophilic disorders, feeding disorders, gastroesophageal reflux and esophagitis, gastrointestinal bleeding, Inflammatory Bowel Disease Center, intestinal failure (short-bowel), irritable bowel syndrome, motility disorders, Liver Clinic, liver diseases and transplantation, metabolic disorders affecting the liver or intestines, poor growth, small bowel transplantation and ulcer disease. The division also provides a full range of diagnostic procedures and treatments related to the gastrointestinal tract, liver and pancreas.

For more information on Dr. Squires and Children’s Hospital of Pittsburgh of UPMC, visit www.chp.edu.

Many Eligible Low-Income Kids with Mental Disabilities Not Getting SSI Benefits, Says IOM Report

PrintMany low-income children with mental disorders who are eligible for federal benefits may not be receiving them, according to a new report from the National Academies of Sciences, Engineering and Medicinethat was co-authored by a researcher from the University of Pittsburgh.

The findings of “Mental Disorders and Disabilities Among Low-Income Children” also noted that the number of children who do receive assistance has been rising in accordance with overall mental health trends and rising poverty rates.

“Federal assistance programs for children with mental disabilities are being underutilized when they could help cover the costs to improve the health and wellbeing of the child and family,” said Amy Houtrow, MD, PhD, MPH, associate professor of physical medicine and rehabilitation and pediatrics, Pitt School of Medicine, who served on the committee that authored the report. “It appears that more kids could benefit from available funding, and the medical community could help eligible families become aware of the benefits and how to apply.”

For the report, the committee examined the U.S. Social Security Administration’s Supplemental Security Income (SSI) program, which provides benefits to low-income people with disabilities.

The percentage of poor children who received federal disability benefits for at least one of 10 major mental disorders increased only slightly from 1.88 percent in 2004 to 2.09 percent in 2013, the report said. While 20 to 50 percent of potentially SSI-eligible kids with autism spectrum disorders received benefits; depending on state of residence, just 4 percent of potentially SSI-eligible kids with oppositional defiant disorder or conduct disorder; and 3 percent of those with mood disorders, received benefits.

“We also found that while the percentage of American children living in impoverished households has increased, particularly during the economic recession from 2008 to 2010,” said Dr. Houtrow, who also is chief, Division of Pediatric Rehabilitation Medicine, at Children’s Hospital of Pittsburgh of UPMC. “Further, the proportion of children who have disabilities has increased every decade since the 1960s. This means that more children should qualify for federal benefits,” she added.

Children’s Hospital of Pittsburgh of UPMC Appoints NIH Immunology Researcher as Mellon Scholar

Dr. Hand is the fourth scientist in the Mellon Scholars Program, which enables promising researchers in the early stages of their careers to pursue potential breakthrough research projects in biomedicine. The scholars are selected on the basis of work that is highly innovative, delivering new expertise to the biomedical research community; likely to lead to major breakthroughs; and capable of having a long-lasting impact on the practice of medicine.

“Dr. Hand exemplifies the type of scientist we’re recruiting to the Mellon Institute at Children’s – someone who early in his or her career has already achieved very promising results, but who also has shown the potential to make an even more significant impact,” said Jay Kolls, M.D., Mellon Institute director. “Dr. Hand has distinguished himself with his work at the National Institutes of Health and we’re excited for him to continue his work at UPMC.”

Dr. Hand’s research focuses on the development and regulation of T-cell responses against microbiota and how gastrointestinal infection may “unleash” the immune response against commensal bacteria and how such responses are controlled to prevent overt pathology.

His research has many applications and may provide insight into a variety of diseases affecting children, including Crohn’s disease, environmental enteropathy and food allergies. His lab will study gastrointestinal immunity to the normal gastrointestinal tract and host-invading pathogens that may disrupt tissue stability.

Dr. Hand comes to Children’s Hospital from the Laboratory of Parasitic Disease at the National Institute of Allergy and Infectious Diseases, in Bethesda, Md., where he has been a post-doctoral fellow since 2009.

He has been an author on numerous publications in prestigious journals including Science, Cell, Immunity, and Cell Host/Microbe, has received a National Institutes of Health transitional “K” award, and was a Food and Drug Administration Office of Dietary Supplements scholar.

Dr. Hand, who also is assistant professor of pediatrics at the University of Pittsburgh School of Medicine, earned his bachelor’s degree from Trinity College, University of Toronto and his doctoral degree from Yale University.

Established through a groundbreaking gift from the Richard King Mellon Foundation, the Institute is an incubator for research that challenges conventional wisdom and can lead to paradigm shifts in pediatric medicine. This kind of high-risk, high-impact investigation is not typically funded through government or conventional sources, placing Children’s Hospital in a unique realm of pediatric research centers.

Located within the John G. Rangos Sr. Research Center on Children’s main campus, the Institute’s faculty and programs are a part of the Pitt School of Medicine. For more information on The Richard King Mellon Foundation Institute for Pediatric Research, please visit www.chp.edu/mellon.

Children’s Hospital of Pittsburgh Foundation Invests in Cardiovascular Regeneration Research

PrintPITTSBURGH, Aug. 20, 2015Bernard Kühn, M.D., a scientist at the Richard King Mellon Foundation Institute for Pediatric Research at Children’s Hospital of Pittsburgh of UPMC, is being awarded a $200,000 grant from the Children’s Hospital of Pittsburgh Foundation.

The grant is being provided from the Fund for Genomic Discovery, which was raised by the Foundation’s Research and Education Program Committee. Established in 2012, the Research and Education Program Committee promotes the awareness of funding needs and priorities of physician-scientists at Children’s Hospital. Through various fundraising initiatives, the committee seeks to broaden the network of philanthropists, raise money to fund the gaps between government grants, and provide seed funding for new avenues of scientific investigation.

Through hosting two events, combined with additional fundraising efforts, more than $520,000 has been raised for research.

“This funding will allow my team to enter the field of fibrosis research, a new area of investigation for my lab. If successful, this project will provide a broadly applicable molecular-genetic blueprint for the field of cardiovascular development and for developing new drugs to reduce fibrosis in heart disease,” said Dr. Kühn, associate professor of pediatrics at the University of Pittsburgh School of Medicine. “Working directly with me on this research is Dennis Kostka, Ph.D., an expert in Developmental Biology and Computational & Systems Biology, who will offer his expertise on the computational aspects of the research.”

Dr. Kühn, also the director of research at Children’s Heart Institute, joined the faculty in September 2014, and has been focused on the unique workings of heart muscle cells. His long-term objective is to provide novel approaches and molecular targets for the treatment of heart failure, primarily by studying the mechanisms of growth and regeneration of the myocardium, the muscle tissue of the heart.

Dr. Kühn and his team of researchers are focused on cardiomyocytes, the cells of the heart muscle, and discovering ways to make them replicate and proliferate so as to enable the heart to heal itself in cases of heart failure or congenital defects.

“Dr. Kühn is one of the leading researchers in heart regeneration and this funding will give him the opportunity to further explore the growth of heart cells and the advancement of treatments for heart failure,” said David H. Perlmutter, M.D., physician-in-chief and scientific director, Children’s Hospital, and Distinguished Professor and Vira I. Heinz Endowed Chair, Department of Pediatrics, Pitt School of Medicine.

Dr. Kühn is the recipient of numerous grants and awards, including the American College of Cardiology’s prestigious Young Investigator Award, the Basil O’Connor Award from the March of Dimes Birth Defects Foundation, and Scientist Development Grant from the American Heart Association.

For more information on Dr. Kühn, please visit www.chp.edu.

Cancer Researcher at Children’s Hospital of Pittsburgh of UPMC Receives Grant from St. Baldrick’s Foundation

PrintPITTSBURGH, Aug. 6, 2015 Edward V. Prochownik, M.D., Ph.D., director of oncology research at Children’s Hospital of Pittsburgh of UPMC, and the Paul C. Gaffney Professor of Pediatrics, has been awarded a research grant of $100,000 from the St. Baldrick’s Foundation, a volunteer-driven charity dedicated to raising money for childhood cancer research.

The award to Dr. Prochownik is one of 70 grants totaling more than $21.1 million nationally and internationally awarded by St. Baldrick’s in support of pediatric oncology research. These grants provide resources to institutions to conduct more research and enroll more children in ongoing clinical trials. Dr. Prochownik and his team will explore the implications of new observations of cancer cell growth.

“Cancer cells must alter their metabolism to provide the necessary energy and metabolic building blocks needed to support their rapid division,” said Dr. Prochownik, who also is professor of molecular genetics and biochemistry, University of Pittsburgh School of Medicine. “We have identified some of the key means by which the cell can control these changes. Confirming and extending these findings as we propose to do could provide novel and specific ways to interfere with this process and thus inhibit tumor growth while minimizing long-term side effects.”

Over the past year, Dr. Prochownik and his research team have developed a model of hepatoblastoma, the most common childhood liver cancer, which in advanced states is difficult to treat and requires use of drugs that can cause long-term toxicities.

“We have discovered that the mitochondria of these hepatoblastoma cells appear to be reprogrammed so as to allow them to function at maximal capacity and thus provide large amounts of energy and metabolic building blocks needed by the rapidly growing and dividing cancer cells,” explained Dr. Prochownik. “We hope that our observations at this level can be translated into new and specific ways of treating this cancer while at the same time reducing toxicity.”

This past year, three St. Baldrick’s head-shaving events were hosted in Pittsburgh, where more than 140 people “braved the shave” and raised nearly $86,000.

For more information about Dr. Prochownik, please visit www.chp.edu.

Kids May Need More Vitamin D, Pitt/Children’s Study Finds

PITTSBURGH, July 9, 2015 – Currently recommended daily dietary allowances of vitamin D may be insufficient to prevent deficiency in children, according to researchers at Children’s Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine. In a report recently published in the Journal of Clinical Endocrinology and Metabolism, they noted that children with suboptimal vitamin D blood levels did not reach optimal levels after taking nearly twice the recommended amount of the nutrient daily for six months.

Vitamin D is important for calcium metabolism and bone health, said lead investigator and Children’s Hospital pediatrician Kumaravel Rajakumar, M.D., M.S., who also is an associate professor of pediatrics at Pitt’s School of Medicine. It is present in a few foods, milk is usually fortified with it and with enough exposure to sunlight the body naturally produces it.

“Vitamin D deficiency is common in the northeastern U.S., especially in black children whose darker skin complexions have higher amounts of melanin, preventing absorption of the ultraviolet light that’s needed to trigger vitamin D synthesis,” he explained.

Guidelines differ on adequate blood levels of vitamin D for bone health, highlighting the need for further research. Blood level of 25-hydroxyvitamin D is the best measure of vitamin D status. For example, a blood level of 20 or more nanograms per milliliter (ng/mL) of the vitamin is considered adequate for bone health by the Institute of Medicine, while the Endocrine Society recommends a level of 30 ng/mL for optimal bone health.

Between October and March of 2008 through 2011, the researchers randomly assigned 84 black and 73 white 8- to 14-year-old children from Pittsburgh and Kittanning, Pa., to take for six months either a daily pill of 1,000 international units (IU) of vitamin D3 or a placebo. They also performed periodic blood tests to assess their 25-hydroxyvitamin D levels and other markers of bone health.

The average vitamin D level at the initial assessment of all children, and particularly black children, was suboptimal (less than 20 ng/mL), and supplementation raised their average level to above 20 ng/mL but not as high as 30 ng/mL. After six months of vitamin D supplementation in children with initial vitamin D levels less than 20 ng/mL, 39 percent remained below 20 ng/mL and only 14 percent rose above 30 ng/mL. Biomarkers of bone turnover remained unchanged.

“Our findings suggest that currently recommended daily dietary allowances of vitamin D of 600 IU may be inadequate for preventing vitamin D deficiency in children,” Dr. Rajakumar said. “It may be important to revisit these recommendations, especially since the higher dose of vitamin D used in this study was safe and did not appear to lead to any side effects.”

The team included Charity G. Moore, Ph.D., M.S.P.H., Jonathan Yabes, Ph.D., Flora Olabopo, B.S., Mary Ann Haralam, M.S.N., Diane Comer, B.A., Susan Sereika, Ph.D., Jacqueline Dunbar-Jacob, Ph.D., and Susan L Greenspan, M.D., all of Pitt; Jaimee Bogusz, B.S., and Michael F. Holick, M.D., Ph.D., both of Boston University School of Medicine; and Anita Nucci, Ph.D., M.P.H., R.D., L.D., of Georgia State University.

The project was funded by National Institutes of Health grants HD052550, DK062895, AG024827, HL112985 and RR024153; and Children’s Hospital of Pittsburgh of UPMC.

Page 1 of 13:1 2 3 4 »Last »