UPMC Physician Resources

Archives for Pediatric Nephrology

Grant Awarded for National Biorepository for GUDMAP Biobank

Sunder Sims-Lucas, PhD, and Jacqueline Ho, MD, are co-investigators on a $600,000 per year grant for 5 years from the National Institutes of Health to be the national biorepository for the GenitoUrinary Development Molecular Anatomy Project (GUDMAP).

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GUDMAP is an international consortium working to generate gene expression data and transgenic mice as tools to study genitourinary development. This curated, high-resolution dataset serves as a powerful resource for biologists, clinicians and bioinformaticians interested in the developing urogenital system.

GUDMAP data is accessible at www.gudmap.org.

Hospitalized Patients at Risk if Sodium Levels are Low

Michael Moritz, MD, explains how hospitalized patients could be at risk of weak bones, and increased infections if physicians ignore low-sodium in the body, known as hyponatremia.

Dr. Moritz is clinical director, Division of Pediatric Nephrology at Children’s Hospital of UPMC and as Professor of Pediatrics at the University of Pittsburgh School of Medicine. Dr. Moritz is an authority on sodium and water metabolism in children.

Hospitalized patients at risk if sodium levels are low – Frontiers Science Hero from Frontiers on Vimeo.

Growing Kidneys in Lymph Nodes

Carl Bates, MD, and Sunder Sims-Lucas, PhD, of the Division of Pediatric Nephrology at Children’s Hospital of Pittsburgh of UPMC, in collaboration with Eric Lagasse, PhD, of the University of Pittsburgh McGowan Institute for Regenerative Medicine, are developing a novel approach to regenerate kidney tissues.

The group has discovered that embryonic kidney fragments and isolated nephron progenitors have the potential to form perfused kidney structures when injected into mouse lymph nodes. The Bates, Sims-Lucas, and Lagasse laboratories have received a Pediatric Device Initiative Award sponsored by the Commonwealth of Pennsylvania in support of their work.

 

Nephrotic Syndrome Symposium

Nephrotic Syndrome: Clinical Challenges and Evidence-based Management
May 12, 2016 – 9:00 a.m. to 6 p.m.
Children’s Hospital of Pittsburgh of UPMC
4401 Penn Ave.
Pittsburgh, PA 15224

Please join us for this one day event will engage glomerular kidney disease researchers, clinicians, other healthcare professionals and patient families. This event promises to foster new collaborations, close the gaps between research and clinical care and form common research agendas.

Course Directors
Agnieszka Swiatecka-Urban, MD
Children’s Hospital of Pittsburgh of UPMC,
University of Pittsburgh School of Medicine

Hoda Kaldas, MD
University of Pittsburgh

To view the Save the Date flyer, click here.
For more information or to register, click here.

 

Officials Announce New Chair of Pediatrics at Pitt and Scientific Director of Children’s Hospital of Pittsburgh of UPMC

PrintTerence S. Dermody, MD, has been named the new chair of the Department of Pediatrics at the University of Pittsburgh School of Medicine and physician-in-chief and scientific director at Children’s Hospital of Pittsburgh of UPMC.

Dr. Dermody will officially begin on June 1. He joins Children’s Hospital from Vanderbilt University, where he is the Dorothy Overall Wells Professor of Pediatrics, director of the Division of Pediatric Infectious Diseases, and director of the Medical Scientist Training Program at Vanderbilt University School of Medicine. He also is a professor of pathology, microbiology and immunology at Vanderbilt.

“Terry Dermody is a world renowned researcher, compassionate physician, visionary leader and just an all-around first class person,” said Christopher Gessner, president, Children’s Hospital. “We are thrilled that he will be joining our team as we continue to grow our clinical and research programs and make Children’s the place to be for pediatric physicians and physician scientists to launch and build their careers.”

Dr. Dermody is a virologist with interests in viral pathogenesis and vaccine development. He has focused mainly on reovirus, an important experimental model for studies of viral encephalitis in infants, and on chikungunya virus, an arthropod-borne virus that causes epidemics of febrile arthritis.

The work in Dr. Dermody’s lab has encompassed several inter-related themes including the structural basis of viral attachment and cell entry, mechanisms of genome replication and packaging, patterns of cell signaling and gene expression occurring in response to viral infection, mechanisms of virus-induced apoptosis and its significance in the viral life cycle, and the role of viral receptor distribution and utilization in disease pathology. Currently, the lab is developing viral vectors for oncolytic and vaccine applications.

“Dr. Dermody came highly recommended by leaders in our Department of Pediatrics,” noted Arthur S. Levine, M.D., senior vice chancellor for the health sciences and John and Gertrude Petersen Dean of Medicine, University of Pittsburgh. “His academic interests, which included running Vanderbilt’s M.D./Ph.D. training program, are unusually broad. An exceptional physician and scientist, he will be an asset to our faculty, residents and students.”

“I am honored to be able to join the team in Pittsburgh and be a part of this world-class pediatric facility dedicated to improving the lives of children,” said Dr. Dermody. “I am eager to begin and have the opportunity to work with the talented physicians and scientists at Children’s Hospital. I feel honored and humbled to have this opportunity.”

Dr. Dermody succeeds David H. Perlmutter, M.D., who recently left Children’s to become executive vice chancellor for medical affairs and dean of medicine at Washington University in St. Louis.

Dr. Dermody received his bachelor’s degree from Cornell University in 1978, and his medical degree from Columbia University in 1982. He completed an internal medicine residency at Presbyterian Hospital in New York in 1985 and fellowships in infectious diseases and molecular virology at Brigham and Women’s Hospital and Harvard Medical School in 1988.

He has authored or co-authored more than 200 articles, reviews and chapters about his research, which is supported by grants from the National Institutes of Health (NIH) and the Lamb Foundation. He currently holds five NIH grants, and his research has been continually funded by the NIH since 1987.

He has been recognized for his research accomplishments with the Ernest W. Goodpasture Faculty Research Award, the Grant W. Liddle Award for Leadership in the Promotion of Scientific Research, and an NIH MERIT Award. He is a past president of the American Society for Virology, past chair of the AAMC GREAT Group M.D./Ph.D. Section Steering Committee, and current chair of the Virology Division of the International Union of Microbiological Societies.

For more information on Dr. Dermody and Children’s Hospital of Pittsburgh of UPMC, visit www.chp.edu.

- See more at: http://www.chp.edu/news/011116-new-pediatrics-chair#sthash.Wr8mpdQv.dpuf

Leaders in Kidney Development Research

Pediatric Division of Nephrology faculty, Carlton Bates, MD, and Jacqueline Ho, MD, have recently been recognized for their work on kidney development research. One of the key missions of the Division of Pediatric Nephrology is to extend the knowledge of pathophysiology of renal disease through basic laboratory and clinical research.

Dr. Bates was elected to the American Society for Clinical Investigation; the medical honor society recognizes physicians who have accomplished meritorious original, creative, and independent investigations in the clinical or allied sciences of medicine. Dr. Bates studies genetic mouse models of kidney and lower urinary tract development. By suppressing or altering the activity of certain genes, he and his team are able to breed mice with structural kidney disease akin to what is seen in affected children, leading to new insights into the causes of congenital kidney and bladder diseases, which are leading causes of pediatric chronic kidney disease.

Dr. Ho was recently awarded a prestigious RO1 research grant by the NIH. She also has received numerous research awards, including the 2014 March of Dimes Basil O’Connor Starter Scholar Research Award and the 2013 International Pediatric Nephrology Association Renée Habib Young Investigator Award.

Children’s Hospital of Pittsburgh of UPMC Named One of America’s Top 10 Children’s Hospitals

PITTSBURGH, June 10, 2014 – Children’s Hospital of Pittsburgh of UPMC has been named one of America’s Best Children’s Hospitals by U.S. News & World Report.

Children’s Hospital ranks ninth on the magazine’s 2014-15 Honor Roll of America’s Best Children’s Hospitals, which was released today. Children’s also ranks in each of the 10 pediatrics specialties ranked by U.S. News. This is the fifth consecutive year Children’s has been named to U.S. News’ Honor Roll.

The Best Children’s Hospitals rankings highlight the top 50 U.S. pediatric hospitals in each of 10 specialties: cancer; cardiology and heart surgery; diabetes and endocrinology; gastroenterology and GI surgery; neonatology; nephrology; neurology and neurosurgery; orthopaedics; pulmonology; and urology.

Children’s ranked in the top 25 of all 10 specialties, including fifth in diabetes and endocrinology; sixth in gastroenterology and GI surgery; sixth in pulmonology; eighth in neonatology; and ninth in neurology and neurosurgery.

“Our inclusion on the honor roll and our rankings in each of the 10 specialties speaks to the breadth and depth of our clinical programs,” said Christopher Gessner, Children’s president. “It speaks to the expertise and commitment of our physicians, nurses and other staff who make Children’s Hospital a global leader in pediatric health care.”

The 2014-15 Best Children’s Hospitals rankings will be released online today and also will be published in the U.S. News Best Hospitals 2015 guidebook, available in August.

In addition to Children’s Hospital of Pittsburgh of UPMC, the other hospitals named to U.S. News’ Honor Roll of Best Children’s Hospitals for 2014-15 are:

  • Boston Children’s Hospital
  • Children’s Hospital of Philadelphia
  • Cincinnati Children’s Hospital Medical Center
  • Texas Children’s Hospital, Houston
  • Children’s Hospital Los Angeles
  • Children’s Hospital Colorado, Aurora
  • Nationwide Children’s Hospital, Columbus, Ohio
  • Ann and Robert H. Lurie Children’s Hospital of Chicago
  • Johns Hopkins Children’s Center, Baltimore